Product nameNoscapine, antimitotic agent
DescriptionAntitussive, antimitotic agent; non-addictive.
A phthalide isoquinoline non-narcotic alkaloid derived from the opium poppy Papaver somniferum, with antitussive, and potential antineoplastic activities. Exerts its antitussive effects through the activation of sigma opioid receptors. Exerts its antimitotic effect by binding to tubulin, resulting in a disruption of microtubule assembly dynamics and subsequently, the inhibition of mitosis and tumor cell death.
Storage instructionsShipped at 4°C. Store at -20°C. Store under desiccating conditions.
Under Inert Atmosphere.
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This product has been referenced in:
- Rida PC et al. The Noscapine Chronicle: A Pharmaco-Historic Biography of the Opiate Alkaloid Family and its Clinical Applications. Med Res Rev 35:1072-96 (2015). Read more (PubMed: 26179481) »
- Chen X et al. Noscapine comes of age. Phytochemistry 111:7-13 (2015). Read more (PubMed: 25583437) »
- DeBono A et al. Progress Toward the Development of Noscapine and Derivatives as Anticancer Agents. J Med Chem 58:5699-727 (2015). Read more (PubMed: 25811651) »
- Singh H et al. A review on noscapine, and its impact on heme metabolism. Curr Drug Metab 14:351-60 (2013). Read more (PubMed: 22935070) »
- Alisaraie L & Tuszynski JA Determination of noscapine's localization and interaction with the tubulin-a/ß heterodimer. Chem Biol Drug Des 78:535-46 (2011). Read more (PubMed: 21781284) »
- SEGAL MS et al. The use of noscapine (narcotine) as an antitussive agent. Dis Chest 32:305-9 (1957). Read more (PubMed: 13461774) »