Recombinant Anti-Notch1 antibody [EP1238Y] (ab52627)

Rabbit recombinant monoclonal Notch1 antibody [EP1238Y]. Validated in WB, IHC, Flow Cyt, ICC/IF and tested in Mouse, Cow, Human. Cited in 67 publication(s). Independently reviewed in 10 review(s).

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ab52627 has been referenced in 78 publications.

  • Lv L  et al. MicroRNA-495 targets Notch1 to prohibit cell proliferation and invasion in oral squamous cell carcinoma. Mol Med Rep 19:693-702 (2019). PubMed: 30387817
  • Li S  et al. Notch1 inhibition enhances DNA damage induced by cisplatin in cervical cancer. Exp Cell Res 376:27-38 (2019). PubMed: 30690027
  • Wang Q  et al. Enhanced chemotherapeutic efficacy of the low-dose doxorubicin in breast cancer via nanoparticle delivery system crosslinked hyaluronic acid. Drug Deliv 26:12-22 (2019). PubMed: 30691317
  • Wang P  et al. Shear stress promotes differentiation of stem cells from human exfoliated deciduous teeth into endothelial cells via the downstream pathway of VEGF-Notch signaling. Int J Mol Med 42:1827-1836 (2018). PubMed: 30015843
  • Xu H  et al. NFIX Circular RNA Promotes Glioma Progression by Regulating miR-34a-5p via Notch Signaling Pathway. Front Mol Neurosci 11:225 (2018). PubMed: 30072869
  • Kahn SA  et al. Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma. Nat Commun 9:4121 (2018). PubMed: 30297829
  • Hao B  et al. Yes-associated protein 1 promotes the metastasis of U251 glioma cells by upregulating Jagged-1 expression and activating the Notch signal pathway. Exp Ther Med 16:1411-1416 (2018). PubMed: 30112068
  • Tao Z  et al. Autophagy suppresses self-renewal ability and tumorigenicity of glioma-initiating cells and promotes Notch1 degradation. Cell Death Dis 9:1063 (2018). PubMed: 30337536
  • Zheng X  et al. MicroRNA-221 promotes cell proliferation, migration, and differentiation by regulation of ZFPM2 in osteoblasts. Braz J Med Biol Res 51:e7574 (2018). PubMed: 30365725
  • Chen XD  et al. Effects of porcine acellular dermal matrix treatment on wound healing and scar formation: Role of Jag1 expression in epidermal stem cells. Organogenesis 14:25-35 (2018). PubMed: 29420128
  • Liu X  et al. BMP9 overexpressing adipose-derived mesenchymal stem cells promote cartilage repair in osteoarthritis-affected knee joint via the Notch1/Jagged1 signaling pathway. Exp Ther Med 16:4623-4631 (2018). PubMed: 30542413
  • Stepp MA  et al. Molecular basis of Mitomycin C enhanced corneal sensory nerve repair after debridement wounding. Sci Rep 8:16960 (2018). PubMed: 30446696
  • Cheng H  et al. HtrA1 suppresses the growth of pancreatic cancer cells by modulating Notch-1 expression. Braz J Med Biol Res 52:e7718 (2018). PubMed: 30484491
  • Pagie S  et al. Notch signaling triggered via the ligand DLL4 impedes M2 macrophage differentiation and promotes their apoptosis. Cell Commun Signal 16:4 (2018). PubMed: 29321062
  • Ernst AK  et al. Knockdown of L1CAM significantly reduces metastasis in a xenograft model of human melanoma: L1CAM is a potential target for anti-melanoma therapy. PLoS One 13:e0192525 (2018). PubMed: 29432466
  • Wang W  et al. Lycium barbarum Polysaccharide Promotes Maturation of Dendritic Cell via Notch Signaling and Strengthens Dendritic Cell Mediated T Lymphocyte Cytotoxicity on Colon Cancer Cell CT26-WT. Evid Based Complement Alternat Med 2018:2305683 (2018). PubMed: 29619065
  • Ding Y  et al. Deubiquitinase inhibitor b-AP15 activates endoplasmic reticulum (ER) stress and inhibits Wnt/Notch1 signaling pathway leading to the reduction of cell survival in hepatocellular carcinoma cells. Eur J Pharmacol 825:10-18 (2018). PubMed: 29454609
  • Liang Z & Ren C Emodin attenuates apoptosis and inflammation induced by LPS through up-regulating lncRNA TUG1 in murine chondrogenic ATDC5 cells. Biomed Pharmacother 103:897-902 (2018). WB ; Mouse . PubMed: 29710506
  • Lin J  et al. FBW7 is associated with prognosis, inhibits malignancies and enhances temozolomide sensitivity in glioblastoma cells. Cancer Sci 109:1001-1011 (2018). WB ; Human . PubMed: 29427543
  • Du Z  et al. HepaCAM inhibits the malignant behavior of castration-resistant prostate cancer cells by downregulating Notch signaling and PF-3084014 (a ?-secretase inhibitor) partly reverses the resistance of refractory prostate cancer to docetaxel and enzalutamide in vitro. Int J Oncol 53:99-112 (2018). PubMed: 29658567
  • Yang Z  et al. Down-regulation of microRNA-23b aggravates LPS-induced inflammatory injury in chondrogenic ATDC5 cells by targeting PDCD4. Iran J Basic Med Sci 21:529-535 (2018). PubMed: 29922435
  • Fan H  et al. Effect of Notch1 gene on remyelination in multiple sclerosis in mouse models of acute demyelination. J Cell Biochem N/A:N/A (2018). PubMed: 30010211
  • Ninh VK  et al. Chronic Ethanol Administration Prevents Compensatory Cardiac Hypertrophy in Pressure Overload. Alcohol Clin Exp Res N/A:N/A (2018). PubMed: 29846943
  • Bai L  et al. Knockdown of MALAT1 enhances chemosensitivity of ovarian cancer cells to cisplatin through inhibiting the Notch1 signaling pathway. Exp Cell Res 366:161-171 (2018). WB ; Human . PubMed: 29548748
  • Shi H  et al. Human induced pluripotent stem cell-derived mesenchymal stem cells alleviate atherosclerosis by modulating inflammatory responses. Mol Med Rep 17:1461-1468 (2018). PubMed: 29257199
  • Wang J  et al. Function and mechanism of microRNA-210 in acute cerebral infarction. Exp Ther Med 15:1263-1268 (2018). PubMed: 29434712
  • Liao W  et al. Antitumor activity of Notch-1 inhibition in human colorectal carcinoma cells. Oncol Rep 39:1063-1071 (2018). PubMed: 29286145
  • Liu Y  et al. RUNX3 modulates hypoxia-induced endothelial-to-mesenchymal transition of human cardiac microvascular endothelial cells. Int J Mol Med 40:65-74 (2017). PubMed: 28534977
  • Wang P  et al. Basic fibroblast growth factor reduces scar by inhibiting the differentiation of epidermal stem cells to myofibroblasts via the Notch1/Jagged1 pathway. Stem Cell Res Ther 8:114 (2017). WB ; Rat, Rabbit . PubMed: 28511663
  • Zhang X  et al. MicroRNA-34a suppresses colorectal cancer metastasis by regulating Notch signaling. Oncol Lett 14:2325-2333 (2017). PubMed: 28781671
  • Lee JC  et al. Obesogenic diet-induced gut barrier dysfunction and pathobiont expansion aggravate experimental colitis. PLoS One 12:e0187515 (2017). PubMed: 29107964
  • Subramani B  et al. Impaired redox environment modulates cardiogenic and ion-channel gene expression in cardiac-resident and non-resident mesenchymal stem cells. Exp Biol Med (Maywood) 242:645-656 (2017). PubMed: 28092181
  • Zhang J  et al. Differential expression of the Notch1 receptor, and its ligands Dll1, Dll3 and Dll4 in distinct human pituitary adenoma subtypes. Oncol Lett 13:4533-4539 (2017). PubMed: 28599454
  • Zhang Y  et al. Involvement of Notch2 in all-trans retinoic acid-induced inhibition of mouse embryonic palate mesenchymal cell proliferation. Mol Med Rep 16:2538-2546 (2017). PubMed: 28713967
  • Shi FT  et al. Notch signaling is significantly suppressed in basal cell carcinomas and activation induces basal cell carcinoma cell apoptosis. Mol Med Rep 15:1441-1454 (2017). IHC-P ; Human . PubMed: 28259916
  • Li GJ  et al. Slit2 suppresses endothelial cell proliferation and migration by inhibiting the VEGF-Notch signaling pathway. Mol Med Rep 15:1981-1988 (2017). WB ; Rat . PubMed: 28260032
  • Gulati S  et al. Attenuation of opioid tolerance by ETB receptor agonist, IRL-1620, is independent of an accompanied decrease in nerve growth factor in mice. Heliyon 3:e00317 (2017). WB ; Mouse . PubMed: 28626808
  • Zhang C  et al. Autophagy is involved in mouse kidney development and podocyte differentiation regulated by Notch signalling. J Cell Mol Med 21:1315-1328 (2017). IF . PubMed: 28158917
  • Liu Y  et al. KRASG12 mutant induces the release of the WSTF/NRG3 complex, and contributes to an oncogenic paracrine signaling pathway. Oncotarget 7:53153-53164 (2016). PubMed: 27449290
  • Chen X  et al. Suppression of HSP27 increases the anti-tumor effects of quercetin in human leukemia U937 cells. Mol Med Rep 13:689-96 (2016). WB ; Human . PubMed: 26648539
  • Denicolaï E  et al. Molecular heterogeneity of glioblastomas: does location matter? Oncotarget 7:902-13 (2016). IHC . PubMed: 26637806
  • Stoyanova T  et al. Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer. Proc Natl Acad Sci U S A 113:E6457-E6466 (2016). WB . PubMed: 27694579
  • Wu X  et al. Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis. Nat Commun 7:10533 (2016). WB, Flow Cyt, ICC/IF ; Mouse, Human . PubMed: 26837467
  • Huang B  et al. Dysregulation of Notch and ERa signaling in AhR-/- male mice. Proc Natl Acad Sci U S A 113:11883-11888 (2016). IHC, ICC/IF . PubMed: 27688768
  • Shao H  et al. Notch1-WISP-1 axis determines the regulatory role of mesenchymal stem cell-derived stromal fibroblasts in melanoma metastasis. Oncotarget 7:79262-79273 (2016). WB ; Mouse . PubMed: 27813493
  • Peng C  et al. Norcantharidin Suppresses Colon Cancer Cell Epithelial-Mesenchymal Transition by Inhibiting the avß6-ERK-Ets1 Signaling Pathway. Sci Rep 6:20500 (2016). PubMed: 26846153
  • Pamarthy S  et al. The V-ATPase a2 isoform controls mammary gland development through Notch and TGF-ß signaling. Cell Death Dis 7:e2443 (2016). PubMed: 27809299
  • Astudillo L  et al. The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. Cancer Res 76:3593-603 (2016). PubMed: 27197169
  • Qiu Y  et al. Vaccarin attenuates high glucose-induced human EA•hy926 endothelial cell injury through inhibition of Notch signaling. Mol Med Rep 13:2143-50 (2016). PubMed: 26795539
  • Yu JB  et al. Aberrant Notch signaling in glioblastoma stem cells contributes to tumor recurrence and invasion. Mol Med Rep 14:1263-8 (2016). PubMed: 27315154
  • Shao H  et al. Notch1 Pathway Activity Determines the Regulatory Role of Cancer-Associated Fibroblasts in Melanoma Growth and Invasion. PLoS One 10:e0142815 (2015). PubMed: 26562315
  • Moutal A  et al. CRMP5 Controls Glioblastoma Cell Proliferation and Survival through Notch-Dependent Signaling. Cancer Res 75:3519-28 (2015). PubMed: 26122847
  • Pan Z  et al. The Expression of Markers Related to Ovarian Germline Stem Cells in the Mouse Ovarian Surface Epithelium and the Correlation with Notch Signaling Pathway. Cell Physiol Biochem 37:2311-22 (2015). PubMed: 26645720
  • Xie F  et al. Vaccarin attenuates the human EA.hy926 endothelial cell oxidative stress injury through inhibition of Notch signaling. Int J Mol Med 35:135-42 (2015). WB . PubMed: 25352009
  • Riess JW  et al. GLI1, CTNNB1 and NOTCH1 protein expression in a thymic epithelial malignancy tissue microarray. Anticancer Res 35:669-76 (2015). PubMed: 25667444
  • Gomi K  et al. Activation of NOTCH1 or NOTCH3 signaling skews human airway basal cell differentiation toward a secretory pathway. PLoS One 10:e0116507 (2015). IHC . PubMed: 25700162
  • Singh NK  et al. Cyclic AMP Response Element Binding Protein Mediates Pathological Retinal Neovascularization via Modulating DLL4-NOTCH1 Signaling. EBioMedicine 2:1767-84 (2015). PubMed: 26870802
  • Redmond EM  et al. Perivascular delivery of Notch 1 siRNA inhibits injury-induced arterial remodeling. PLoS One 9:e84122 (2014). WB ; Mouse . PubMed: 24416200
  • Gonzalez ME  et al. EZH2 expands breast stem cells through activation of NOTCH1 signaling. Proc Natl Acad Sci U S A 111:3098-103 (2014). PubMed: 24516139
  • Bohn O  et al. Utility of LRF/Pokemon and NOTCH1 protein expression in the distinction between nodular lymphocyte-predominant Hodgkin lymphoma and classical Hodgkin lymphoma. Int J Surg Pathol 22:6-11 (2014). PubMed: 24326827
  • Sliwa T  et al. Hyperexpression of NOTCH-1 is found in immature acute myeloid leukemia. Int J Clin Exp Pathol 7:882-9 (2014). IHC-P ; Human . PubMed: 24695418
  • Qiu M  et al. FOXA1 promotes tumor cell proliferation through AR involving the Notch pathway in endometrial cancer. BMC Cancer 14:78 (2014). WB, IHC-P ; Human . PubMed: 24512546
  • Schwarzer R  et al. Notch pathway inhibition controls myeloma bone disease in the murine MOPC315.BM model. Blood Cancer J 4:e217 (2014). WB . PubMed: 24927406
  • Zhang X  et al. FADD regulates thymocyte development at the ß-selection checkpoint by modulating Notch signaling. Cell Death Dis 5:e1273 (2014). ICC/IF ; Mouse . PubMed: 24901044
  • Camps J  et al. Genetic amplification of the NOTCH modulator LNX2 upregulates the WNT/ß-catenin pathway in colorectal cancer. Cancer Res 73:2003-13 (2013). PubMed: 23319804
  • Benner EJ  et al. Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4. Nature 497:369-73 (2013). PubMed: 23615612
  • Su Y  et al. PSMA specific single chain antibody-mediated targeted knockdown of Notch1 inhibits human prostate cancer cell proliferation and tumor growth. Cancer Lett 338:282-91 (2013). Human . PubMed: 23752065
  • Giannelli M  et al. Photoactivation of bone marrow mesenchymal stromal cells with diode laser: Effects and mechanisms of action. J Cell Physiol 228:172-81 (2013). Mouse . PubMed: 22628164
  • Yasen M  et al. Changes of number of cells expressing proliferation and progenitor cell markers with age in rabbit intervertebral discs. Acta Biochim Biophys Sin (Shanghai) 45:368-76 (2013). PubMed: 23449074
  • Magnani L  et al. Genome-wide reprogramming of the chromatin landscape underlies endocrine therapy resistance in breast cancer. Proc Natl Acad Sci U S A 110:E1490-9 (2013). PubMed: 23576735
  • Suprynowicz FA  et al. Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells. Proc Natl Acad Sci U S A 109:20035-40 (2012). WB ; Human . PubMed: 23169653
  • Sakamoto K  et al. Reduction of NOTCH1 expression pertains to maturation abnormalities of keratinocytes in squamous neoplasms. Lab Invest 92:688-702 (2012). WB, IHC-P ; Human . PubMed: 22330335
  • Bailey AR  et al. Aberrant T-lymphocyte development and function in mice overexpressing human soluble amyloid precursor protein-a: implications for autism. FASEB J 26:1040-51 (2012). PubMed: 22085641
  • Lim SO  et al. Notch1 binds and induces degradation of Snail in hepatocellular carcinoma. BMC Biol 9:83 (2011). ICC/IF ; Human . PubMed: 22128911
  • Ma J  et al. Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. J Clin Invest 120:103-14 (2010). PubMed: 20038814
  • Hanlon L  et al. Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma. Cancer Res 70:4280-6 (2010). PubMed: 20484026
  • Wei P  et al. Evaluation of selective gamma-secretase inhibitor PF-03084014 for its antitumor efficacy and gastrointestinal safety to guide optimal clinical trial design. Mol Cancer Ther 9:1618-28 (2010). PubMed: 20530712
  • Firestein R  et al. CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. Nature 455:547-51 (2008). Human . PubMed: 18794900

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