Recombinant
RabMAb

Recombinant Anti-Notch1 antibody [EP1238Y] (ab52627)

Rabbit recombinant monoclonal Notch1 antibody [EP1238Y]. Validated in WB, IHC, Flow Cyt, ICC/IF and tested in Mouse, Cow, Human. Cited in 67 publication(s). Independently reviewed in 10 review(s).

Publishing research using ab52627? Please let us know so that we can cite the reference in this datasheet.

ab52627 has been referenced in 78 publications.

  • Lv L  et al. MicroRNA-495 targets Notch1 to prohibit cell proliferation and invasion in oral squamous cell carcinoma. Mol Med Rep 19:693-702 (2019). PubMed: 30387817
  • Li S  et al. Notch1 inhibition enhances DNA damage induced by cisplatin in cervical cancer. Exp Cell Res 376:27-38 (2019). PubMed: 30690027
  • Wang Q  et al. Enhanced chemotherapeutic efficacy of the low-dose doxorubicin in breast cancer via nanoparticle delivery system crosslinked hyaluronic acid. Drug Deliv 26:12-22 (2019). PubMed: 30691317
  • Wang P  et al. Shear stress promotes differentiation of stem cells from human exfoliated deciduous teeth into endothelial cells via the downstream pathway of VEGF-Notch signaling. Int J Mol Med 42:1827-1836 (2018). PubMed: 30015843
  • Xu H  et al. NFIX Circular RNA Promotes Glioma Progression by Regulating miR-34a-5p via Notch Signaling Pathway. Front Mol Neurosci 11:225 (2018). PubMed: 30072869
  • Kahn SA  et al. Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma. Nat Commun 9:4121 (2018). PubMed: 30297829
  • Hao B  et al. Yes-associated protein 1 promotes the metastasis of U251 glioma cells by upregulating Jagged-1 expression and activating the Notch signal pathway. Exp Ther Med 16:1411-1416 (2018). PubMed: 30112068
  • Tao Z  et al. Autophagy suppresses self-renewal ability and tumorigenicity of glioma-initiating cells and promotes Notch1 degradation. Cell Death Dis 9:1063 (2018). PubMed: 30337536
  • Zheng X  et al. MicroRNA-221 promotes cell proliferation, migration, and differentiation by regulation of ZFPM2 in osteoblasts. Braz J Med Biol Res 51:e7574 (2018). PubMed: 30365725
  • Chen XD  et al. Effects of porcine acellular dermal matrix treatment on wound healing and scar formation: Role of Jag1 expression in epidermal stem cells. Organogenesis 14:25-35 (2018). PubMed: 29420128
  • Liu X  et al. BMP9 overexpressing adipose-derived mesenchymal stem cells promote cartilage repair in osteoarthritis-affected knee joint via the Notch1/Jagged1 signaling pathway. Exp Ther Med 16:4623-4631 (2018). PubMed: 30542413
  • Stepp MA  et al. Molecular basis of Mitomycin C enhanced corneal sensory nerve repair after debridement wounding. Sci Rep 8:16960 (2018). PubMed: 30446696
  • Cheng H  et al. HtrA1 suppresses the growth of pancreatic cancer cells by modulating Notch-1 expression. Braz J Med Biol Res 52:e7718 (2018). PubMed: 30484491
  • Pagie S  et al. Notch signaling triggered via the ligand DLL4 impedes M2 macrophage differentiation and promotes their apoptosis. Cell Commun Signal 16:4 (2018). PubMed: 29321062
  • Ernst AK  et al. Knockdown of L1CAM significantly reduces metastasis in a xenograft model of human melanoma: L1CAM is a potential target for anti-melanoma therapy. PLoS One 13:e0192525 (2018). PubMed: 29432466
  • Wang W  et al. Lycium barbarum Polysaccharide Promotes Maturation of Dendritic Cell via Notch Signaling and Strengthens Dendritic Cell Mediated T Lymphocyte Cytotoxicity on Colon Cancer Cell CT26-WT. Evid Based Complement Alternat Med 2018:2305683 (2018). PubMed: 29619065
  • Ding Y  et al. Deubiquitinase inhibitor b-AP15 activates endoplasmic reticulum (ER) stress and inhibits Wnt/Notch1 signaling pathway leading to the reduction of cell survival in hepatocellular carcinoma cells. Eur J Pharmacol 825:10-18 (2018). PubMed: 29454609
  • Liang Z & Ren C Emodin attenuates apoptosis and inflammation induced by LPS through up-regulating lncRNA TUG1 in murine chondrogenic ATDC5 cells. Biomed Pharmacother 103:897-902 (2018). WB ; Mouse . PubMed: 29710506
  • Lin J  et al. FBW7 is associated with prognosis, inhibits malignancies and enhances temozolomide sensitivity in glioblastoma cells. Cancer Sci 109:1001-1011 (2018). WB ; Human . PubMed: 29427543
  • Du Z  et al. HepaCAM inhibits the malignant behavior of castration-resistant prostate cancer cells by downregulating Notch signaling and PF-3084014 (a ?-secretase inhibitor) partly reverses the resistance of refractory prostate cancer to docetaxel and enzalutamide in vitro. Int J Oncol 53:99-112 (2018). PubMed: 29658567
  • Yang Z  et al. Down-regulation of microRNA-23b aggravates LPS-induced inflammatory injury in chondrogenic ATDC5 cells by targeting PDCD4. Iran J Basic Med Sci 21:529-535 (2018). PubMed: 29922435
  • Fan H  et al. Effect of Notch1 gene on remyelination in multiple sclerosis in mouse models of acute demyelination. J Cell Biochem N/A:N/A (2018). PubMed: 30010211
  • Ninh VK  et al. Chronic Ethanol Administration Prevents Compensatory Cardiac Hypertrophy in Pressure Overload. Alcohol Clin Exp Res N/A:N/A (2018). PubMed: 29846943
  • Bai L  et al. Knockdown of MALAT1 enhances chemosensitivity of ovarian cancer cells to cisplatin through inhibiting the Notch1 signaling pathway. Exp Cell Res 366:161-171 (2018). WB ; Human . PubMed: 29548748
  • Shi H  et al. Human induced pluripotent stem cell-derived mesenchymal stem cells alleviate atherosclerosis by modulating inflammatory responses. Mol Med Rep 17:1461-1468 (2018). PubMed: 29257199
  • Wang J  et al. Function and mechanism of microRNA-210 in acute cerebral infarction. Exp Ther Med 15:1263-1268 (2018). PubMed: 29434712
  • Liao W  et al. Antitumor activity of Notch-1 inhibition in human colorectal carcinoma cells. Oncol Rep 39:1063-1071 (2018). PubMed: 29286145
  • Liu Y  et al. RUNX3 modulates hypoxia-induced endothelial-to-mesenchymal transition of human cardiac microvascular endothelial cells. Int J Mol Med 40:65-74 (2017). PubMed: 28534977
  • Wang P  et al. Basic fibroblast growth factor reduces scar by inhibiting the differentiation of epidermal stem cells to myofibroblasts via the Notch1/Jagged1 pathway. Stem Cell Res Ther 8:114 (2017). WB ; Rat, Rabbit . PubMed: 28511663
  • Zhang X  et al. MicroRNA-34a suppresses colorectal cancer metastasis by regulating Notch signaling. Oncol Lett 14:2325-2333 (2017). PubMed: 28781671
  • Lee JC  et al. Obesogenic diet-induced gut barrier dysfunction and pathobiont expansion aggravate experimental colitis. PLoS One 12:e0187515 (2017). PubMed: 29107964
  • Subramani B  et al. Impaired redox environment modulates cardiogenic and ion-channel gene expression in cardiac-resident and non-resident mesenchymal stem cells. Exp Biol Med (Maywood) 242:645-656 (2017). PubMed: 28092181
  • Zhang J  et al. Differential expression of the Notch1 receptor, and its ligands Dll1, Dll3 and Dll4 in distinct human pituitary adenoma subtypes. Oncol Lett 13:4533-4539 (2017). PubMed: 28599454
  • Zhang Y  et al. Involvement of Notch2 in all-trans retinoic acid-induced inhibition of mouse embryonic palate mesenchymal cell proliferation. Mol Med Rep 16:2538-2546 (2017). PubMed: 28713967
  • Shi FT  et al. Notch signaling is significantly suppressed in basal cell carcinomas and activation induces basal cell carcinoma cell apoptosis. Mol Med Rep 15:1441-1454 (2017). IHC-P ; Human . PubMed: 28259916
  • Li GJ  et al. Slit2 suppresses endothelial cell proliferation and migration by inhibiting the VEGF-Notch signaling pathway. Mol Med Rep 15:1981-1988 (2017). WB ; Rat . PubMed: 28260032
  • Gulati S  et al. Attenuation of opioid tolerance by ETB receptor agonist, IRL-1620, is independent of an accompanied decrease in nerve growth factor in mice. Heliyon 3:e00317 (2017). WB ; Mouse . PubMed: 28626808
  • Zhang C  et al. Autophagy is involved in mouse kidney development and podocyte differentiation regulated by Notch signalling. J Cell Mol Med 21:1315-1328 (2017). IF . PubMed: 28158917
  • Liu Y  et al. KRASG12 mutant induces the release of the WSTF/NRG3 complex, and contributes to an oncogenic paracrine signaling pathway. Oncotarget 7:53153-53164 (2016). PubMed: 27449290
  • Chen X  et al. Suppression of HSP27 increases the anti-tumor effects of quercetin in human leukemia U937 cells. Mol Med Rep 13:689-96 (2016). WB ; Human . PubMed: 26648539
  • Denicolaï E  et al. Molecular heterogeneity of glioblastomas: does location matter? Oncotarget 7:902-13 (2016). IHC . PubMed: 26637806
  • Stoyanova T  et al. Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer. Proc Natl Acad Sci U S A 113:E6457-E6466 (2016). WB . PubMed: 27694579
  • Wu X  et al. Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis. Nat Commun 7:10533 (2016). WB, Flow Cyt, ICC/IF ; Mouse, Human . PubMed: 26837467
  • Huang B  et al. Dysregulation of Notch and ERa signaling in AhR-/- male mice. Proc Natl Acad Sci U S A 113:11883-11888 (2016). IHC, ICC/IF . PubMed: 27688768
  • Shao H  et al. Notch1-WISP-1 axis determines the regulatory role of mesenchymal stem cell-derived stromal fibroblasts in melanoma metastasis. Oncotarget 7:79262-79273 (2016). WB ; Mouse . PubMed: 27813493
  • Peng C  et al. Norcantharidin Suppresses Colon Cancer Cell Epithelial-Mesenchymal Transition by Inhibiting the avß6-ERK-Ets1 Signaling Pathway. Sci Rep 6:20500 (2016). PubMed: 26846153
  • Pamarthy S  et al. The V-ATPase a2 isoform controls mammary gland development through Notch and TGF-ß signaling. Cell Death Dis 7:e2443 (2016). PubMed: 27809299
  • Astudillo L  et al. The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. Cancer Res 76:3593-603 (2016). PubMed: 27197169
  • Qiu Y  et al. Vaccarin attenuates high glucose-induced human EA•hy926 endothelial cell injury through inhibition of Notch signaling. Mol Med Rep 13:2143-50 (2016). PubMed: 26795539
  • Yu JB  et al. Aberrant Notch signaling in glioblastoma stem cells contributes to tumor recurrence and invasion. Mol Med Rep 14:1263-8 (2016). PubMed: 27315154
  • Shao H  et al. Notch1 Pathway Activity Determines the Regulatory Role of Cancer-Associated Fibroblasts in Melanoma Growth and Invasion. PLoS One 10:e0142815 (2015). PubMed: 26562315
  • Moutal A  et al. CRMP5 Controls Glioblastoma Cell Proliferation and Survival through Notch-Dependent Signaling. Cancer Res 75:3519-28 (2015). PubMed: 26122847
  • Pan Z  et al. The Expression of Markers Related to Ovarian Germline Stem Cells in the Mouse Ovarian Surface Epithelium and the Correlation with Notch Signaling Pathway. Cell Physiol Biochem 37:2311-22 (2015). PubMed: 26645720
  • Xie F  et al. Vaccarin attenuates the human EA.hy926 endothelial cell oxidative stress injury through inhibition of Notch signaling. Int J Mol Med 35:135-42 (2015). WB . PubMed: 25352009
  • Riess JW  et al. GLI1, CTNNB1 and NOTCH1 protein expression in a thymic epithelial malignancy tissue microarray. Anticancer Res 35:669-76 (2015). PubMed: 25667444
  • Gomi K  et al. Activation of NOTCH1 or NOTCH3 signaling skews human airway basal cell differentiation toward a secretory pathway. PLoS One 10:e0116507 (2015). IHC . PubMed: 25700162
  • Singh NK  et al. Cyclic AMP Response Element Binding Protein Mediates Pathological Retinal Neovascularization via Modulating DLL4-NOTCH1 Signaling. EBioMedicine 2:1767-84 (2015). PubMed: 26870802
  • Redmond EM  et al. Perivascular delivery of Notch 1 siRNA inhibits injury-induced arterial remodeling. PLoS One 9:e84122 (2014). WB ; Mouse . PubMed: 24416200
  • Gonzalez ME  et al. EZH2 expands breast stem cells through activation of NOTCH1 signaling. Proc Natl Acad Sci U S A 111:3098-103 (2014). PubMed: 24516139
  • Bohn O  et al. Utility of LRF/Pokemon and NOTCH1 protein expression in the distinction between nodular lymphocyte-predominant Hodgkin lymphoma and classical Hodgkin lymphoma. Int J Surg Pathol 22:6-11 (2014). PubMed: 24326827
  • Sliwa T  et al. Hyperexpression of NOTCH-1 is found in immature acute myeloid leukemia. Int J Clin Exp Pathol 7:882-9 (2014). IHC-P ; Human . PubMed: 24695418
  • Qiu M  et al. FOXA1 promotes tumor cell proliferation through AR involving the Notch pathway in endometrial cancer. BMC Cancer 14:78 (2014). WB, IHC-P ; Human . PubMed: 24512546
  • Schwarzer R  et al. Notch pathway inhibition controls myeloma bone disease in the murine MOPC315.BM model. Blood Cancer J 4:e217 (2014). WB . PubMed: 24927406
  • Zhang X  et al. FADD regulates thymocyte development at the ß-selection checkpoint by modulating Notch signaling. Cell Death Dis 5:e1273 (2014). ICC/IF ; Mouse . PubMed: 24901044
  • Camps J  et al. Genetic amplification of the NOTCH modulator LNX2 upregulates the WNT/ß-catenin pathway in colorectal cancer. Cancer Res 73:2003-13 (2013). PubMed: 23319804
  • Benner EJ  et al. Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4. Nature 497:369-73 (2013). PubMed: 23615612
  • Su Y  et al. PSMA specific single chain antibody-mediated targeted knockdown of Notch1 inhibits human prostate cancer cell proliferation and tumor growth. Cancer Lett 338:282-91 (2013). Human . PubMed: 23752065
  • Giannelli M  et al. Photoactivation of bone marrow mesenchymal stromal cells with diode laser: Effects and mechanisms of action. J Cell Physiol 228:172-81 (2013). Mouse . PubMed: 22628164
  • Yasen M  et al. Changes of number of cells expressing proliferation and progenitor cell markers with age in rabbit intervertebral discs. Acta Biochim Biophys Sin (Shanghai) 45:368-76 (2013). PubMed: 23449074
  • Magnani L  et al. Genome-wide reprogramming of the chromatin landscape underlies endocrine therapy resistance in breast cancer. Proc Natl Acad Sci U S A 110:E1490-9 (2013). PubMed: 23576735
  • Suprynowicz FA  et al. Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells. Proc Natl Acad Sci U S A 109:20035-40 (2012). WB ; Human . PubMed: 23169653
  • Sakamoto K  et al. Reduction of NOTCH1 expression pertains to maturation abnormalities of keratinocytes in squamous neoplasms. Lab Invest 92:688-702 (2012). WB, IHC-P ; Human . PubMed: 22330335
  • Bailey AR  et al. Aberrant T-lymphocyte development and function in mice overexpressing human soluble amyloid precursor protein-a: implications for autism. FASEB J 26:1040-51 (2012). PubMed: 22085641
  • Lim SO  et al. Notch1 binds and induces degradation of Snail in hepatocellular carcinoma. BMC Biol 9:83 (2011). ICC/IF ; Human . PubMed: 22128911
  • Ma J  et al. Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. J Clin Invest 120:103-14 (2010). PubMed: 20038814
  • Hanlon L  et al. Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma. Cancer Res 70:4280-6 (2010). PubMed: 20484026
  • Wei P  et al. Evaluation of selective gamma-secretase inhibitor PF-03084014 for its antitumor efficacy and gastrointestinal safety to guide optimal clinical trial design. Mol Cancer Ther 9:1618-28 (2010). PubMed: 20530712
  • Firestein R  et al. CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. Nature 455:547-51 (2008). Human . PubMed: 18794900

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