Anti-NOTCH3 antibody (ab92758)

Rabbit polyclonal NOTCH3 antibody. Validated in IHC and tested in Rat, Human. Immunogen corresponding to synthetic peptide.


  • Product name

  • Description

    Rabbit polyclonal to NOTCH3
  • Host species

  • Tested applications

    Suitable for: IHC-Frmore details
  • Species reactivity

    Reacts with: Rat, Human
  • Immunogen

    Synthetic peptide representing the C terminal region of Human NOTCH3.

  • Positive control

    • Rat cerebellum



Our Abpromise guarantee covers the use of ab92758 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notes
    IHC-Fr: 1/100 - 1/300.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs.
    • Tissue specificity

      Ubiquitously expressed in fetal and adult tissues.
    • Involvement in disease

      Defects in NOTCH3 are the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) [MIM:125310]. CADASIL causes a type of stroke and dementia of which key features include recurrent subcortical ischemic events and vascular dementia. The disorder affects relatively young adults of both sexes. Mutations affect highly conserved cysteine residues within epidermal growth factor (EGF)-like repeat domains in the extracellular part of the receptor.
    • Sequence similarities

      Belongs to the NOTCH family.
      Contains 5 ANK repeats.
      Contains 34 EGF-like domains.
      Contains 3 LNR (Lin/Notch) repeats.
    • Post-translational

      Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane.
    • Cellular localization

      Cell membrane and Nucleus. Following proteolytical processing NICD is translocated to the nucleus.
    • Information by UniProt
    • Database links

    • Alternative names

      • CADASIL antibody
      • CASIL antibody
      • NOTC3_HUMAN antibody
      • Notch 3 antibody
      • Notch 3 intracellular domain antibody
      • Notch homolog 3 antibody
      • Notch3 antibody
      see all


    • ab92758 at 1/100 dilution staining NOTCH3 in (Bergmann glia-10 micron cryostat sections) rat cerebellum by Immunohistochemistry.


    ab92758 has not yet been referenced specifically in any publications.

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