Overview

  • Product name

  • Description

    Rabbit polyclonal to NOX1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 242-271 of Human NOX1 (NP_008983.2, NP_039249.1).

  • Positive control

    • WiDr cell line lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab130478 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 65 kDa.

Target

  • Function

    NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain.
  • Tissue specificity

    NOH-1L is detected in colon, uterus, prostate, and colon carcinoma, but not in peripheral blood leukocytes. NOH-1S is detected only in colon and colon carcinoma cells.
  • Sequence similarities

    Contains 1 FAD-binding FR-type domain.
    Contains 1 ferric oxidoreductase domain.
  • Cellular localization

    Cell projection > invadopodium membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • GP91 2 antibody
    • Mitogenic oxidase (pyridine nucleotide dependent superoxide generating) antibody
    • Mitogenic oxidase 1 antibody
    • MOX-1 antibody
    • MOX1 antibody
    • NADH/NADPH mitogenic oxidase subunit P65 MOX antibody
    • NADH/NADPH mitogenic oxidase subunit P65-MOX antibody
    • NADPH oxidase 1 antibody
    • NADPH oxidase 1 variant NOH 1L antibody
    • NADPH oxidase homolog 1 antibody
    • NOH 1 antibody
    • NOH-1 antibody
    • NOH1 antibody
    • NOX-1 antibody
    • Nox1 antibody
    • NOX1_HUMAN antibody
    • RP1 146H21.1 antibody
    see all

Images

  • Anti-NOX1 antibody (ab130478) at 1/100 dilution + WiDr cell line lysate at 35 µg

    Predicted band size: 65 kDa

References

This product has been referenced in:

  • Clotaire DZJ  et al. miR-19b-3p integrates Jak-Stat signaling pathway through Plzf to regulate self-renewal in dairy goat male germline stem cells. Int J Biochem Cell Biol 105:104-114 (2018). Read more (PubMed: 30393202) »
See 1 Publication for this product

Customer reviews and Q&As

Answer

Thanks for your enquiry.

I looked up NOX1 expression in the human protein atlas (http://www.proteinatlas.org/ENSG00000007952/cancer) and it shows that NOX1 should show a strong signal in colon cancer tissues, thus the HT-29 cells should be a good positive control.



Please let us know if you have further questions.

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