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    nox1-antibody-ab131088.pdf

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Immunology Adaptive Immunity T Cells Cytotoxic Cells
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Anti-NOX1 antibody (ab131088)

  • Datasheet
  • SDS
Submit a review Submit a question References (19)

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Western blot - Anti-NOX1 antibody (ab131088)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NOX1 antibody (ab131088)

Key features and details

  • Rabbit polyclonal to NOX1
  • Suitable for: WB, IHC-P
  • Reacts with: Mouse, Rat
  • Isotype: IgG

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Overview

  • Product name

    Anti-NOX1 antibody
    See all NOX1 primary antibodies
  • Description

    Rabbit polyclonal to NOX1
  • Host species

    Rabbit
  • Tested Applications & Species

    Application Species
    IHC-P
    Rat
    WB
    Rat
    See all applications and species data
  • Immunogen

    Synthetic peptide corresponding to an internal sequence of Rat NOX1.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage buffer

    Preservatives: 0.025% Thimerosal (merthiolate), 0.025% Sodium azide
    Constituents: 2.5% BSA, 0.1% Dibasic monohydrogen sodium phosphate, 0.45% Sodium chloride
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Immunology
    • Adaptive Immunity
    • T Cells
    • Cytotoxic Cells
    • Epigenetics and Nuclear Signaling
    • DNA / RNA
    • DNA Damage & Repair
    • DNA Damage Response
    • Other
    • Signal Transduction
    • Metabolism
    • Plasma Membrane
    • Channels
    • Cell Biology
    • Other Antibodies
    • Oxidative Stress
    • Metabolism
    • Pathways and Processes
    • Metabolic signaling pathways
    • Nucleotide metabolism
    • Metabolism
    • Pathways and Processes
    • Redox metabolism
    • Oxidative stress

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab131088 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Guaranteed

Tested applications are guaranteed to work and covered by our Abpromise guarantee.

Predicted

Predicted to work for this combination of applications and species but not guaranteed.

Incompatible

Does not work for this combination of applications and species.

Application Species
IHC-P
Rat
WB
Rat
Application Abreviews Notes
WB
Use a concentration of 0.1 - 0.5 µg/ml. Predicted molecular weight: 65 kDa.
IHC-P
Use a concentration of 0.5 - 1 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
Notes
WB
Use a concentration of 0.1 - 0.5 µg/ml. Predicted molecular weight: 65 kDa.
IHC-P
Use a concentration of 0.5 - 1 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function

    NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain.
  • Tissue specificity

    NOH-1L is detected in colon, uterus, prostate, and colon carcinoma, but not in peripheral blood leukocytes. NOH-1S is detected only in colon and colon carcinoma cells.
  • Sequence similarities

    Contains 1 FAD-binding FR-type domain.
    Contains 1 ferric oxidoreductase domain.
  • Cellular localization

    Cell projection > invadopodium membrane.
  • Target information above from: UniProt accession Q9Y5S8 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 237038 Mouse
    • Entrez Gene: 114243 Rat
    • SwissProt: Q8CIZ9 Mouse
    • SwissProt: Q9WV87 Rat
    • Unigene: 233865 Mouse
    • Unigene: 455133 Mouse
    • Unigene: 220465 Rat
    • Alternative names

      • GP91 2 antibody
      • Mitogenic oxidase (pyridine nucleotide dependent superoxide generating) antibody
      • Mitogenic oxidase 1 antibody
      • MOX-1 antibody
      • MOX1 antibody
      • NADH/NADPH mitogenic oxidase subunit P65 MOX antibody
      • NADH/NADPH mitogenic oxidase subunit P65-MOX antibody
      • NADPH oxidase 1 antibody
      • NADPH oxidase 1 variant NOH 1L antibody
      • NADPH oxidase homolog 1 antibody
      • NOH 1 antibody
      • NOH-1 antibody
      • NOH1 antibody
      • NOX-1 antibody
      • Nox1 antibody
      • NOX1_HUMAN antibody
      • RP1 146H21.1 antibody
      see all

    Images

    • Western blot - Anti-NOX1 antibody (ab131088)
      Western blot - Anti-NOX1 antibody (ab131088)
      All lanes : Anti-NOX1 antibody (ab131088)

      Lane 1 : Rat heart tissue lysate
      Lane 2 : Rat brain tissue lysate
      Lanes 3-4 : Mouse heart tissue lysate

      Predicted band size: 65 kDa

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NOX1 antibody (ab131088)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NOX1 antibody (ab131088)

      ab131088 staining NOX1 in Rat kidney tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections).

    Protocols

    • Western blot protocols
    • Immunohistochemistry protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
    • SDS
  • References (19)

    Publishing research using ab131088? Please let us know so that we can cite the reference in this datasheet.

    ab131088 has been referenced in 19 publications.

    • Liao CR  et al. Advanced oxidation protein products increase TNF-a and IL-1ß expression in chondrocytes via NADPH oxidase 4 and accelerate cartilage degeneration in osteoarthritis progression. Redox Biol 28:101306 (2020). PubMed: 31539804
    • Liu Z  et al. IFI6 depletion inhibits esophageal squamous cell carcinoma progression through reactive oxygen species accumulation via mitochondrial dysfunction and endoplasmic reticulum stress. J Exp Clin Cancer Res 39:144 (2020). PubMed: 32727517
    • Leger T  et al. Dietary EPA Increases Rat Mortality in Diabetes Mellitus, A Phenomenon Which Is Compensated by Green Tea Extract. Antioxidants (Basel) 8:N/A (2019). PubMed: 31690052
    • Palacios-Ramírez R  et al. Pioglitazone Modulates the Vascular Contractility in Hypertension by Interference with ET-1 Pathway. Sci Rep 9:16461 (2019). PubMed: 31712626
    • Xu T  et al. NADPH oxidase 2-mediated NLRP1 inflammasome activation involves in neuronal senescence in hippocampal neurons in vitro. Int Immunopharmacol 69:60-70 (2019). PubMed: 30677569
    View all Publications for this product

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