Anti-Noxa antibody [ABM46B8] (ab220177)
Key features and details
- Rat monoclonal [ABM46B8] to Noxa
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG2b
Overview
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Product name
Anti-Noxa antibody [ABM46B8]
See all Noxa primary antibodies -
Description
Rat monoclonal [ABM46B8] to Noxa -
Host species
Rat -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse -
Immunogen
Recombinant full length protein corresponding to Mouse Noxa aa 1 to the C-terminus.
Database link: Q9JM54 -
Positive control
- T98G lysate.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.05% Sodium azide
Constituents: 99% PBS, 0.05% BSA -
Concentration information loading...
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Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
ABM46B8 -
Isotype
IgG2b -
Light chain type
kappa -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab220177 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB |
Use a concentration of 2 - 4 µg/ml. Predicted molecular weight: 12 kDa.
Predicted Band: 6kDa (Human) |
Notes |
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WB
Use a concentration of 2 - 4 µg/ml. Predicted molecular weight: 12 kDa. Predicted Band: 6kDa (Human) |
Target
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Function
Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. -
Tissue specificity
Highly expressed in adult T-cell leukemia cell line. -
Sequence similarities
Belongs to the PMAIP1 family. -
Domain
The BH3 motif is essential for pro-apoptotic activity. -
Cellular localization
Mitochondrion. - Information by UniProt
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Database links
- Entrez Gene: 5366 Human
- Entrez Gene: 58801 Mouse
- Omim: 604959 Human
- SwissProt: Q13794 Human
- SwissProt: Q9JM54 Mouse
- Unigene: 96 Human
- Unigene: 271878 Mouse
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Alternative names
- Adult T cell leukemia derived PMA responsive antibody
- APR antibody
- APR_HUMAN antibody
see all
Datasheets and documents
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Datasheet download
References (0)
ab220177 has not yet been referenced specifically in any publications.