Key features and details
- Rat monoclonal [ABM46B8] to Noxa
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG2b
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.05% Sodium azide
Constituents: 99% PBS, 0.05% BSA
Concentration information loading...
PurityProtein G purified
Light chain typekappa
Our Abpromise guarantee covers the use of ab220177 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 2 - 4 µg/ml. Predicted molecular weight: 12 kDa.
Predicted Band: 6kDa (Human)
FunctionPromotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
Tissue specificityHighly expressed in adult T-cell leukemia cell line.
Sequence similaritiesBelongs to the PMAIP1 family.
DomainThe BH3 motif is essential for pro-apoptotic activity.
- Information by UniProt
- Adult T cell leukemia derived PMA responsive antibody
- APR antibody
- APR_HUMAN antibody
ab220177 has not yet been referenced specifically in any publications.