Key features and details
- Rabbit polyclonal to NOXO1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-NOXO1 antibody
DescriptionRabbit polyclonal to NOXO1
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Synthetic peptide, corresponding to a region within amino acids 307-370 of Human NOXO1 (NP_653204)
- HCT116 whole cell lysate.
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Storage instructionsShipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferpH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab97788 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/1000. Predicted molecular weight: 41 kDa.|
FunctionConstitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.
Tissue specificityExpressed in testis, small and large intestines, liver, kidney and pancreas. Isoform 3 is mainly expressed in colon. Isoform 1 is preferentially expressed in testis.
Sequence similaritiesContains 1 PX (phox homology) domain.
Contains 2 SH3 domains.
Developmental stageIsoform 3 is expressed in fetal liver.
DomainThe PX domain mediates lipid-binding, localization to the plasma membrane and is required for NOX1 activation.
The SH3 domains mediate interaction with CYBA/p22phox. Also mediates intramolecular interaction with the proline-rich region.
Cellular localizationCell membrane. Isoform 3 associates with the plasma membrane in a lipid-dependent manner.
- Information by UniProt
- NADPH oxidase organizer 1 antibody
- NADPH oxidase regulatory protein antibody
- Nox organizer 1 antibody
ab97788 has not yet been referenced specifically in any publications.