Overview

  • Product name

    NPC-15437, PKC inhibitor
  • Description

    PKC inhibitor
  • Biological description

    PKC inhibitor (IC50 = 19 μM). Interacts with regulatory domain at residues 12-42. Neuroprotective agent. Active in vivo and in vitro.
  • Purity

    > 98%
  • CAS Number

    141774-20-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (S)-2,6-Diamino-N-[(1-(1-oxotridecyl)-2-piperidinyl)methyl]hexanamide dihydrochloride
  • Molecular weight

    511.61
  • Molecular formula

    C25H50N4O2.2HCl
  • PubChem identifier

    19778249
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCCCCCCCCCCCC(=O)N1CCCCC1CNC(=O)C(CCCCN)N.Cl.Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Mathis C  et al. The selective protein kinase C inhibitor, NPC 15437, induces specific deficits in memory retention in mice. Eur J Pharmacol 220:107-10 (1992). Read more (PubMed: 1425976) »
  • Sullivan JP  et al. 2,6-Diamino-N-([1-oxotridecyl)-2-piperidinyl]methyl)hexanamide (NPC 15437): a selective inhibitor of protein kinase C. Agents Actions 34:142-4 (1991). Read more (PubMed: 1793019) »
  • Sullivan JP  et al. NPC 15437 interacts with the C1 domain of protein kinase C. An analysis using mutant PKC constructs. FEBS Lett 285:120-3 (1991). Read more (PubMed: 2065775) »

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