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    npr-b-peptide-ab150296.pdf

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Neuroscience Neurotransmission Intracellular Signaling Phosphatases
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NPR-B peptide (ab150296)

  • Datasheet
  • SDS
Submit a review Q&A (1)

Product price, shipping and contact information

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Shipping and order information

Abpromise

Guaranteed product quality, expert customer support.

Find out more.

Key features and details

  • Suitable for: Blocking

Description

  • Product name

    NPR-B peptide
    See all NPR-B proteins and peptides
  • Animal free

    No
  • Nature

    Synthetic

Associated products

  • Corresponding Antibody

    • Anti-NPR-A + NPR-B antibody [EPR5719(2)] (ab139188)

Specifications

Our Abpromise guarantee covers the use of ab150296 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-NPR-A + NPR-B antibody [EPR5719(2)] (ab139188)

  • Form

    Liquid
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names

    • AMDM
    • ANP-B
    • ANPB
    • ANPR-B
    • ANPRB
    • ANPRB_HUMAN
    • Atrial natriuretic peptide B type receptor
    • Atrial natriuretic peptide receptor 2
    • Atrial natriuretic peptide receptor type B
    • Atrionatriuretic peptide receptor B
    • GC-B
    • GCB
    • Guanylate cyclase B
    • GUC 2B
    • GUC2B
    • GUCY2B
    • Natriuretic peptide receptor B
    • Natriuretic peptide receptor B/guanylate cyclase B
    • NPR-B
    • Npr2
    • NPRB
    • NPRBi
    see all
  • Function

    Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth.
  • Involvement in disease

    Defects in NPR2 are the cause of acromesomelic dysplasia Maroteaux type (AMDM) [MIM:602875]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers). AMDM is an autosomal recessive form characterized by axial skeletal involvement with wedging of vertebral bodies. In AMDM all skeletal elements are present but show abnormal rates of linear growth.
  • Sequence similarities

    Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
    Contains 1 guanylate cyclase domain.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications

    Phosphorylation of the protein kinase-like domain is required for full activation by CNP.
  • Cellular localization

    Membrane.
  • Target information above from: UniProt accession P20594 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download

References (0)

Publishing research using ab150296? Please let us know so that we can cite the reference in this datasheet.

ab150296 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Question

send Uniprot entry
blocking peptides available?
for ab79164: will test in mouse

Read More

Abcam community

Verified customer

Asked on Nov 19 2012

Answer

Thank you for your patience.

I have heard back from the lab that the blocking peptide for ab116680 has been added to the catalog as ab151530: https://www.abcam.com/natriuretic-peptide-receptor-a-ab151530.html

The blocking peptide for ab139188 has been added as ab150296: https://www.abcam.com/NPR-B-peptide-ab150296.html

Both items will be in stock in 1-2 weeks once an order is placed.


I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

Free Rabbit monoclonal antibody with any purchase of a primary antibody, while stocks last! Quote “RABMAB-XBSMG” in your next primary antibody order. For more information, visit the following link: https://www.abcam.com/index.html?pageconfig=resource&rid=15447

Read More

Abcam Scientific Support

Answered on Nov 19 2012

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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