Overview

  • Product name

    Anti-NPRL2 antibody - N-terminal
    See all NPRL2 primary antibodies
  • Description

    Rabbit polyclonal to NPRL2 - N-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Recombinant fragment corresponding to Human NPRL2 aa 1-220 (N terminal).
    Sequence:

    MGSGCRIECI FFSEFHPTLG PKITYQVPED FISRELFDTV QVYIITKPEL QNKLITVTAM EKKLIGCPVC IEHKKYSRNA LLFNLGFVCD AQAKTCALEP IVKKLAGYLT TLELESSFVS MEESKQKLVP IMTILLEELN ASGRCTLPID ESNTIHLKVI EQRPDPPVAQ EYDVPVFTKD KEDFFNSQWD LTTQQILPYI DGFRHIQKIS AEADVELNLV


    Database link: Q8WTW4

  • Positive control

    • HL60, U937 and mouse brain extracts.
  • General notes

    Previously labelled as NPR2L. 

Properties

Applications

Our Abpromise guarantee covers the use of ab189852 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 44 kDa.
IHC-P 1/50 - 1/200.

Target

  • Function

    Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs.
  • Tissue specificity

    Most abundant in skeletal muscle, followed by brain, liver and pancreas, with lower amounts in lung, kidney, placenta and heart. Expressed in most lung cancer cell lines tested.
  • Sequence similarities

    Belongs to the NPR2 family.
  • Information by UniProt
  • Database links

  • Alternative names

    • 2810446G01Rik antibody
    • G21 protein antibody
    • Gene 21 protein antibody
    • Homologous to yeast nitrogen permease (candidate tumor suppressor) antibody
    • Homologous to yeast nitrogen permease antibody
    • Nitrogen permease regulator 2-like protein antibody
    • Nitrogen permease regulator-like 2 (S. cerevisiae) antibody
    • NPR 2L antibody
    • NPR L2 antibody
    • NPR like 2 antibody
    • NPR2 antibody
    • NPR2 like antibody
    • NPR2-like protein antibody
    • NPR2L antibody
    • NPRL 2 antibody
    • NPRL2 antibody
    • NPRL2_HUMAN antibody
    • Tumor suppressor candidate 4 antibody
    • TUSC 4 antibody
    • TUSC 4 protein antibody
    • TUSC4 antibody
    • TUSC4 protein antibody
    see all

Images

  • All lanes : Anti-NPRL2 antibody - N-terminal (ab189852) at 1/500 dilution

    Lane 1 : HL60 cell extract
    Lane 2 : U937 cell extract
    Lane 3 : Mouse brain extract

    Predicted band size: 44 kDa

References

ab189852 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab189852.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up