NPS 2143 hydrochloride, Ca2+-sensing receptor antagonist (ab145050)

Overview

  • Product name

    NPS 2143 hydrochloride, Ca2+-sensing receptor antagonist
  • Description

    Potent, selective Ca2+-sensing receptor antagonist
  • Biological description

    Potent, selective Ca2+-sensing receptor antagonist (IC50 = 43 nM). Stimulates parathyroid hormone secretion (EC50 = 41 nM). Shows antihypertensive effects in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    324523-20-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride
  • Molecular weight

    445.39
  • Molecular formula

    C24H25ClN2O2.HCl
  • Storage instructions

    Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 10 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Cl.N#Cc1c(cccc1Cl)OCC(O)CNC(C)(C)Cc2cc3ccccc3cc2
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Breitwieser GE Pharmacoperones and the calcium sensing receptor: exogenous and endogenous regulators. Pharmacol Res 83:30-7 (2014). Read more (PubMed: 24291533) »
  • Yamamura A Pathological function of Ca2+-sensing receptor in pulmonary arterial hypertension. J Smooth Muscle Res 50:8-17 (2014). Read more (PubMed: 24770445) »
  • Koori K  et al. The roles of calcium-sensing receptor and calcium channel in osteogenic differentiation of undifferentiated periodontal ligament cells. Cell Tissue Res : (2014). Read more (PubMed: 24842051) »

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