Key features and details
- Rabbit polyclonal to NR0B2
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-NR0B2 antibody
See all NR0B2 primary antibodies
DescriptionRabbit polyclonal to NR0B2
Tested applicationsSuitable for: WB, IHC-Pmore details
Species reactivityReacts with: Human
Recombinant fragment, corresponding to a region within the internal sequence amino acids 64-246 of Human NR0B2.
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferpH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab96605 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/3000. Predicted molecular weight: 28 kDa.|
|IHC-P||1/100 - 1/250.|
FunctionActs as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1.
Tissue specificityLiver. Low levels of expression were detected in heart and pancreas.
Involvement in diseaseObesity
Sequence similaritiesBelongs to the nuclear hormone receptor family. NR0 subfamily.
modificationsArginine methylation by PRMT5 enhances repression activity of metabolic genes in liver in response to bile acid signaling, by increasing interaction with cofactors.
Cellular localizationNucleus. Cytoplasm. Colocalizes with NEUROD1 in the nucleus.
- Information by UniProt
- NR0B2 antibody
- NR0B2_HUMAN antibody
- Nr0b2a antibody
ab96605 has been referenced in 2 publications.
- Gallo-Ebert C et al. Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease. J Biol Chem 293:5956-5974 (2018). PubMed: 29491146
- Prestin K et al. Modulation of expression of the nuclear receptor NR0B2 (small heterodimer partner 1) and its impact on proliferation of renal carcinoma cells. Onco Targets Ther 9:4867-78 (2016). WB ; Human . PubMed: 27540300