Overview

  • Product name

    Anti-NR2E1/Tailless/TLX antibody [EPR4491]
    See all NR2E1/Tailless/TLX primary antibodies
  • Description

    Rabbit monoclonal [EPR4491] to NR2E1/Tailless/TLX
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC,IHC-P or IP
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human NR2E1/Tailless/TLX aa 1-100.
    Database link: Q9Y466

  • Positive control

    • Fetal brain, Human hippocampus, SH-SY5Y and Jurkat lysates
  • General notes

     

     

    Previously labelled as NR2E1 / Tailless. 

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab109179 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 43 kDa.
  • Application notes
    Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • Target

    • Function

      Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. May be required for brain development. May be involved in the regulation of retinal development.
    • Tissue specificity

      Brain specific. Present in all brain sections tested, highest levels in the caudate nucleus and hippocampus, weakest levels in the thalamus.
    • Sequence similarities

      Belongs to the nuclear hormone receptor family. NR2 subfamily.
      Contains 1 nuclear receptor DNA-binding domain.
    • Cellular localization

      Nucleus.
    • Information by UniProt
    • Database links

    • Alternative names

      • hTll antibody
      • NR2E1 / Tailless antibody
      • nr2e1 antibody
      • NR2E1_HUMAN antibody
      • Nuclear receptor subfamily 2 group E member 1 antibody
      • Nuclear receptor TLX antibody
      • Orphan nuclear receptor NR2E1 antibody
      • Protein tailless homolog antibody
      • Tailless homolog antibody
      • Tll antibody
      • TLX antibody
      • XTLL antibody
      see all

    Images

    • All lanes : Anti-NR2E1/Tailless/TLX antibody [EPR4491] (ab109179) at 1/1000 dilution

      Lane 1 : Fetal brain lysate
      Lane 2 : Human hippocampus lysate
      Lane 3 : SH-SY5Y lysate
      Lane 4 : Jurkat lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size: 43 kDa

    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    References

    This product has been referenced in:

    • Dueva E  et al. Computer-Aided Discovery of Small Molecule Inhibitors of Transcriptional Activity of TLX (NR2E1) Nuclear Receptor. Molecules 23:N/A (2018). Read more (PubMed: 30441799) »
    See 1 Publication for this product

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab109179.
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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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