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    nr5a2--lrh1-antibody-ab219603.pdf

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Microbiology Interspecies Interaction Host Virus Interaction
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Anti-NR5A2 / LRH1 antibody (ab219603)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NR5A2 / LRH1 antibody (ab219603)

    Key features and details

    • Rabbit polyclonal to NR5A2 / LRH1
    • Suitable for: IHC-P
    • Reacts with: Human
    • Isotype: IgG

    You may also be interested in

    Secondary
    Product image
    Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    Protein
    Recombinant Human NR5A2 / LRH1 protein (ab81844)

    View more associated products

    Overview

    • Product name

      Anti-NR5A2 / LRH1 antibody
      See all NR5A2 / LRH1 primary antibodies
    • Description

      Rabbit polyclonal to NR5A2 / LRH1
    • Host species

      Rabbit
    • Specificity

      BLAST analysis of the peptide immunogen showed no homology with other human proteins.
    • Tested applications

      Suitable for: IHC-Pmore details
    • Species reactivity

      Reacts with: Human
      Predicted to work with: Mouse, Rat, Sheep, Horse, Chicken, Cow, Dog, Pig, Chimpanzee, Zebrafish, Gorilla
    • Immunogen

      Synthetic peptide corresponding to Human NR5A2/ LRH1. 16 amino acid peptide from ligand-binding domain.
      Database link: O00482

    • Positive control

      • Human liver tissue.
    • General notes

      Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

      Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

      We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

      In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

      We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

      Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

      Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
    • Storage buffer

      Preservative: 0.099% Sodium azide
      Constituent: 99% PBS
    • Concentration information loading...
    • Purity

      Immunogen affinity purified
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Microbiology
      • Interspecies Interaction
      • Host Virus Interaction
      • Epigenetics and Nuclear Signaling
      • Transcription
      • Other factors
      • Stem Cells
      • Embryonic Stem Cells
      • Intracellular
      • Developmental Biology
      • Embryogenesis
      • Embryonic stem cells
      • Surface molecules

    Associated products

    • Compatible Secondaries

      • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
      • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    • Isotype control

      • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
    • Recombinant Protein

      • Recombinant Human NR5A2 / LRH1 protein (ab81844)
    • Related Products

      • Recombinant Human NR5A2 / LRH1 protein (ab81844)
      • Recombinant Human NR5A2 / LRH1 protein (ab82070)

    Applications

    Our Abpromise guarantee covers the use of ab219603 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    IHC-P Use a concentration of 10 - 19 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

    Target

    • Function

      Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
    • Tissue specificity

      Abundantly expressed in pancreas, less in liver, very low levels in heart and lung. Expressed in the Hep-G2 cell line. Isoform 1 and isoform 2 seem to be present in fetal and adult liver and Hep-G2 cells.
    • Sequence similarities

      Belongs to the nuclear hormone receptor family. NR5 subfamily.
      Contains 1 nuclear receptor DNA-binding domain.
    • Cellular localization

      Nucleus.
    • Target information above from: UniProt accession O00482 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 395961 Chicken
      • Entrez Gene: 469631 Chimpanzee
      • Entrez Gene: 541305 Cow
      • Entrez Gene: 490252 Dog
      • Entrez Gene: 101142071 Gorilla
      • Entrez Gene: 100009700 Horse
      • Entrez Gene: 2494 Human
      • Entrez Gene: 26424 Mouse
      • Entrez Gene: 100523688 Pig
      • Entrez Gene: 60349 Rat
      • Entrez Gene: 100653388 Sheep
      • Entrez Gene: 30749 Zebrafish
      • Omim: 604453 Human
      • SwissProt: O42101 Chicken
      • SwissProt: O00482 Human
      • SwissProt: P45448 Mouse
      • SwissProt: Q9QWM1 Rat
      • Unigene: 33446 Human
      • Unigene: 16794 Mouse
      • Unigene: 42941 Rat
      see all
    • Alternative names

      • Alpha-1-fetoprotein transcription factor antibody
      • B1-binding factor antibody
      • B1F antibody
      • B1F2 antibody
      • CPF antibody
      • CYP7A promoter-binding factor antibody
      • FTF antibody
      • FTZ F1 antibody
      • FTZ F1beta antibody
      • FTZ-F1 antibody
      • FTZ-F1beta antibody
      • hB1F 2 antibody
      • hB1F antibody
      • hB1F-2 antibody
      • Hepatocytic transcription factor antibody
      • Liver receptor homolog 1 antibody
      • LRH-1 antibody
      • LRH1 antibody
      • Nr5a2 antibody
      • NR5A2_HUMAN antibody
      • Nuclear receptor subfamily 5 group A member 2 antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NR5A2 / LRH1 antibody (ab219603)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NR5A2 / LRH1 antibody (ab219603)

      Immunohistochemical analysis of formalin-fixed and paraffin-embedded Human liver tissue labeling NR5A2 / LRH1 with ab219603 at 19μg/ml dilution.

    Protocols

    • Immunohistochemistry protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab219603? Please let us know so that we can cite the reference in this datasheet.

    ab219603 has not yet been referenced specifically in any publications.

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