Key features and details
- Rabbit polyclonal to NRDP1
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-NRDP1 antibody
See all NRDP1 primary antibodies
DescriptionRabbit polyclonal to NRDP1
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Xenopus laevis, Zebrafish, Orangutan
Recombinant full length protein corresponding to Human NRDP1 aa 1-317.
MGYDVTRFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACITQWFSQQ QTCPVDRSVVTVAHLRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDNLM SHLSDCEHNPKRPVTCEQGCGLEMPKDELPNHNCIKHLRSVVQQQQTRIA ELEKTSAEHKHQLAEQKRDIQLLKAYMRAIRSVNPNLQNLEETIEYNEIL EWVNSLQPARVTRWGGMISTPDAVLQAVIKRSLVESGCPASIVNELIENA HERSWPQGLATLETRQMNRRYYENYVAKRIPGKQAVVVMACENQHMGDDM VQEPGLVMIFAHGVEEI
Database link: Q9H4P4-1
- IHC-P: Human prostate cancer and testis tissue.
Protein previously labeled as NRDP1.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.30
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab235336 in the following tested applications.
|IHC-P||1/20 - 1/200.|
FunctionActs as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88 and Negatively regulates MYD88-dependent production of proinflammatory cytokines but can promote TRIF-dependent production of type I interferon. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state.
Tissue specificityDetected in ovary, testis and prostate.
PathwayProtein modification; protein ubiquitination.
Sequence similaritiesContains 1 RING-type zinc finger.
Contains 1 SIAH-type zinc finger.
modificationsAutoubiquitinated. Autoubiquitination leads to proteasomal degradation. Deubiquitinated by USP8 to get stabilized which induces apoptosis.
- Information by UniProt
- 4930511A05Rik antibody
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- E3 ubiquitin protein ligase NRDP1 antibody
ab235336 has been referenced in 1 publication.
- Zheng J et al. Nrdp1 is involved in hippocampus apoptosis in cardiopulmonary bypass-induced cognitive dysfunction via the regulation of ErbB3 protein levels. Int J Mol Med 43:1747-1757 (2019). PubMed: 30720051