Recombinant
RabMAb

Recombinant Anti-Nrf2 antibody [EP1808Y] - ChIP Grade (ab62352)

Rabbit recombinant monoclonal Nrf2 antibody [EP1808Y]. Validated in WB, IP, IHC, Flow Cyt, ChIP, ICC/IF and tested in Mouse, Human. Cited in 130 publication(s). Independently reviewed in 21 review(s).

Publishing research using ab62352? Please let us know so that we can cite the reference in this datasheet.

ab62352 has been referenced in 176 publications.

  • Wu B  et al. Nrf2 overexpression protects against paraquat-induced A549 cell injury primarily by upregulating P-glycoprotein and reducing intracellular paraquat accumulation. Exp Ther Med 17:1240-1247 (2019). PubMed: 30679998
  • Chen X  et al. Adropin protects against liver injury in nonalcoholic steatohepatitis via the Nrf2 mediated antioxidant capacity. Redox Biol 21:101068 (2019). PubMed: 30684890
  • Enguita M  et al. The cirrhotic liver is depleted of docosahexaenoic acid (DHA), a key modulator of NF-?B and TGFß pathways in hepatic stellate cells. Cell Death Dis 10:14 (2019). PubMed: 30622239
  • Wang X  et al. Effect of Gastrodin on Early Brain Injury and Neurological Outcome After Subarachnoid Hemorrhage in Rats. Neurosci Bull N/A:N/A (2019). PubMed: 30673960
  • Zhang M  et al. Sulforaphane Attenuates Angiotensin II-Induced Vascular Smooth Muscle Cell Migration via Suppression of NOX4/ROS/Nrf2 Signaling. Int J Biol Sci 15:148-157 (2019). PubMed: 30662355
  • Xiao X  et al. LncRNA ENST00000453774.1 contributes to oxidative stress defense dependent on autophagy mediation to reduce extracellular matrix and alleviate renal fibrosis. J Cell Physiol 234:9130-9143 (2019). PubMed: 30317629
  • Dong W  et al. Dynamic cell type-specific expression of Nrf2 after traumatic brain injury in mice. Eur J Neurosci N/A:N/A (2019). PubMed: 30828870
  • Cheng H  et al. Emerging role of EPHX1 in chemoresistance of acute myeloid leukemia by regurlating drug-metabolizing enzymes and apoptotic signaling. Mol Carcinog N/A:N/A (2019). PubMed: 30644597
  • Ling K  et al. Protective effect of a hydrogen sulfide donor on balloon injury-induced restenosis via the Nrf2/HIF-1a signaling pathway. Int J Mol Med 43:1299-1310 (2019). PubMed: 30747216
  • Wada Y  et al. The protective effect of epigallocatechin 3-gallate on mouse pancreatic islets via the Nrf2 pathway. Surg Today N/A:N/A (2019). PubMed: 30730004
  • Wang P  et al. Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis. Nat Commun 10:755 (2019). PubMed: 30765703
  • Keuss MJ  et al. Unanchored tri-NEDD8 inhibits PARP-1 to protect from oxidative stress-induced cell death. EMBO J 38:N/A (2019). PubMed: 30804002
  • Yang L  et al. The Antioxidative Action of ZTP by Increasing Nrf2/ARE Signal Pathway. Evid Based Complement Alternat Med 2019:5421528 (2019). PubMed: 30984274
  • Dang R  et al. Predictable chronic mild stress promotes recovery from LPS-induced depression. Mol Brain 12:42 (2019). PubMed: 31053149
  • Peng H  et al. Dendrobium officinale polysaccharides regulate age-related lineage commitment between osteogenic and adipogenic differentiation. Cell Prolif N/A:e12624 (2019). PubMed: 31038249
  • Han D  et al. Chlorogenic acid promotes the Nrf2/HO-1 anti-oxidative pathway by activating p21Waf1/Cip1 to resist dexamethasone-induced apoptosis in osteoblastic cells. Free Radic Biol Med 137:1-12 (2019). PubMed: 31004750
  • Li B  et al. MIR-144-mediated NRF2 gene silencing inhibits fetal hemoglobin expression in sickle cell disease. Exp Hematol 70:85-96.e5 (2019). PubMed: 30412705
  • Narzt MS  et al. A novel role for NUPR1 in the keratinocyte stress response to UV oxidized phospholipids. Redox Biol 20:467-482 (2019). PubMed: 30466060
  • Liu YW  et al. Neuroprotection of quercetin on central neurons against chronic high glucose through enhancement of Nrf2/ARE/glyoxalase-1 pathway mediated by phosphorylation regulation. Biomed Pharmacother 109:2145-2154 (2019). PubMed: 30551472
  • Wu X  et al. Homocysteine causes vascular endothelial dysfunction by disrupting endoplasmic reticulum redox homeostasis. Redox Biol 20:46-59 (2019). PubMed: 30292945
  • Lu Y  et al. Fibroblast growth factor 21 facilitates peripheral nerve regeneration through suppressing oxidative damage and autophagic cell death. J Cell Mol Med 23:497-511 (2019). PubMed: 30450828
  • Polo S  et al. Treatment With the Delta Opioid Agonist UFP-512 Alleviates Chronic Inflammatory and Neuropathic Pain: Mechanisms Implicated. Front Pharmacol 10:283 (2019). PubMed: 30971925
  • Yisireyili M  et al. Chronic restraint stress induces esophageal fibrosis with enhanced oxidative stress in a murine model. Exp Ther Med 18:1375-1383 (2019). PubMed: 31316626
  • Mao Y  et al. Repair Effects of KGF on Ischemia-Reperfusion-Induced Flap Injury via Activating Nrf2 Signaling. J Surg Res 244:547-557 (2019). PubMed: 31351398
  • Gao Q  et al. SLC27A5 deficiency activates NRF2/TXNRD1 pathway by increased lipid peroxidation in HCC. Cell Death Differ N/A:N/A (2019). PubMed: 31367013
  • Garufi A  et al. Reduced chemotherapeutic sensitivity in high glucose condition: implication of antioxidant response. Oncotarget 10:4691-4702 (2019). PubMed: 31384396
  • Bialk P  et al. Functional Gene Knockout of NRF2 Increases Chemosensitivity of Human Lung Cancer A549 Cells In Vitro and in a Xenograft Mouse Model. Mol Ther Oncolytics 11:75-89 (2018). PubMed: 30505938
  • Qin XY  et al. Arachidonic acid suppresses hepatic cell growth through ROS-mediated activation of transglutaminase. FEBS Open Bio 8:1703-1710 (2018). PubMed: 30338220
  • Liu Y  et al. Nuclear lactate dehydrogenase A senses ROS to produce a-hydroxybutyrate for HPV-induced cervical tumor growth. Nat Commun 9:4429 (2018). PubMed: 30356100
  • Haas JG  et al. Antiviral activity of the mineralocorticoid receptor NR3C2 against Herpes simplex virus Type 1 (HSV-1) infection. Sci Rep 8:15876 (2018). PubMed: 30367157
  • Sekine T  et al. Regulation of NRF2, AP-1 and NF-?B by cigarette smoke exposure in three-dimensional human bronchial epithelial cells. J Appl Toxicol N/A:N/A (2018). PubMed: 30575053
  • Jin X  et al. Involvement of CYP2E1 in the Course of Brain Edema Induced by Subacute Poisoning With 1,2-Dichloroethane in Mice. Front Pharmacol 9:1317 (2018). PubMed: 30524279
  • Arnandis T  et al. Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous Invasion. Dev Cell 47:409-424.e9 (2018). PubMed: 30458137
  • Tian Y  et al. Activation of Nrf2/ARE pathway alleviates the cognitive deficits in PS1V97L-Tg mouse model of Alzheimer's disease through modulation of oxidative stress. J Neurosci Res N/A:N/A (2018). PubMed: 30461032
  • Heo JR  et al. Resveratrol induced reactive oxygen species and endoplasmic reticulum stress-mediated apoptosis, and cell cycle arrest in the A375SM malignant melanoma cell line. Int J Mol Med 42:1427-1435 (2018). PubMed: 29916532
  • Chen DS  et al. Baicalin Attenuates Joint Pain and Muscle Dysfunction by Inhibiting Muscular Oxidative Stress in an Experimental Osteoarthritis Rat Model. Arch Immunol Ther Exp (Warsz) 66:453-461 (2018). PubMed: 30076457
  • Miller DR  et al. Novel CIL-102 derivatives as potential therapeutic agents for docetaxel-resistant prostate cancer. Cancer Lett 436:96-108 (2018). PubMed: 30077739
  • Zhang J  et al. Metformin reverses the resistance mechanism of lung adenocarcinoma cells that knocks down the Nrf2 gene. Oncol Lett 16:6071-6080 (2018). PubMed: 30333878
  • Ma J  et al. Baicalein protects human vitiligo melanocytes from oxidative stress through activation of NF-E2-related factor2 (Nrf2) signaling pathway. Free Radic Biol Med 129:492-503 (2018). PubMed: 30342186
  • Li PC  et al. Bioengineered NRF2-siRNA Is Effective to Interfere with NRF2 Pathways and Improve Chemosensitivity of Human Cancer Cells. Drug Metab Dispos 46:2-10 (2018). PubMed: 29061583
  • Maclean KN  et al. Taurine treatment prevents derangement of the hepatic ?-glutamyl cycle and methylglyoxal metabolism in a mouse model of classical homocystinuria: regulatory crosstalk between thiol and sulfinic acid metabolism. FASEB J 32:1265-1280 (2018). PubMed: 29101223
  • Hassannia B  et al. Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma. J Clin Invest 128:3341-3355 (2018). PubMed: 29939160
  • Qiu L  et al. A Naturally-Occurring Dominant-Negative Inhibitor of Keap1 Competitively against Its Negative Regulation of Nrf2. Int J Mol Sci 19:N/A (2018). PubMed: 30042301
  • Dong H  et al. Long non-coding RNA SNHG14 induces trastuzumab resistance of breast cancer via regulating PABPC1 expression through H3K27 acetylation. J Cell Mol Med 22:4935-4947 (2018). PubMed: 30063126
  • Drusian L  et al. mTORC1 Upregulation Leads to Accumulation of the Oncometabolite Fumarate in a Mouse Model of Renal Cell Carcinoma. Cell Rep 24:1093-1104.e6 (2018). PubMed: 30067967
  • Ni B  et al. Hydroxysafflor yellow A protects against angiotensin II-induced hypertrophy. Mol Med Rep 18:3649-3656 (2018). PubMed: 30132539
  • Jena KK  et al. TRIM16 controls assembly and degradation of protein aggregates by modulating the p62-NRF2 axis and autophagy. EMBO J 37:N/A (2018). PubMed: 30143514
  • Feng R  et al. Nrf2 activation drive macrophages polarization and cancer cell epithelial-mesenchymal transition during interaction. Cell Commun Signal 16:54 (2018). PubMed: 30180849
  • Chen W  et al. MicroRNA-146a-5p enhances ginsenoside Rh2-induced anti-proliferation and the apoptosis of the human liver cancer cell line HepG2. Oncol Lett 16:5367-5374 (2018). PubMed: 30197683
  • Hsieh YH  et al. Ginsenoside Rh2 Ameliorates Lipopolysaccharide-Induced Acute Lung Injury by Regulating the TLR4/PI3K/Akt/mTOR, Raf-1/MEK/ERK, and Keap1/Nrf2/HO-1 Signaling Pathways in Mice. Nutrients 10:N/A (2018). PubMed: 30200495
  • Sindan N  et al. Expression and localization of nuclear factor erythroid 2-related factor 2 in the ovarian tissues of mice at different ages. Exp Ther Med 16:3546-3552 (2018). PubMed: 30233707
  • Gu L  et al. Andrographolide Protects PC12 Cells Against ß-Amyloid-Induced Autophagy-Associated Cell Death Through Activation of the Nrf2-Mediated p62 Signaling Pathway. Int J Mol Sci 19:N/A (2018). PubMed: 30235892
  • Wang SW  et al. Astilbin ameliorates cisplatin-induced nephrotoxicity through reducing oxidative stress and inflammation. Food Chem Toxicol 114:227-236 (2018). Human . PubMed: 29471006
  • Huang CL  et al. Gastrodia elata alleviates mutant huntingtin aggregation through mitochondrial function and biogenesis mediation. Phytomedicine 39:75-84 (2018). PubMed: 29433686
  • Fang J  et al. Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7. Aging Cell N/A:e12765 (2018). PubMed: 29659168
  • Hu Q  et al. dCK negatively regulates the NRF2/ARE axis and ROS production in pancreatic cancer. Cell Prolif 51:e12456 (2018). PubMed: 29701272
  • Liu Y  et al. Breviscapine ameliorates CCl4-induced liver injury in mice through inhibiting inflammatory apoptotic response and ROS generation. Int J Mol Med 42:755-768 (2018). PubMed: 29717768
  • Gray NE  et al. Centella asiatica increases hippocampal synaptic density and improves memory and executive function in aged mice. Brain Behav 8:e01024 (2018). PubMed: 29920983
  • Huang X  et al. Functional role of BTB and CNC Homology 1 gene in pancreatic cancer and its association with survival in patients treated with gemcitabine. Theranostics 8:3366-3379 (2018). PubMed: 29930735
  • Yuki H  et al. Increased Nrf2 expression by renal cell carcinoma is associated with postoperative chronic kidney disease and an unfavorable prognosis. Oncotarget 9:28351-28363 (2018). PubMed: 29983865
  • Gao Y  et al. Migration and invasion in B16-F10 mouse melanoma cells are regulated by Nrf2 inhibition during treatment with ionizing radiation. Oncol Lett 16:1959-1966 (2018). PubMed: 30008889
  • Zhou X  et al. Resveratrol represses estrogen-induced mammary carcinogenesis through NRF2-UGT1A8-estrogen metabolic axis activation. Biochem Pharmacol 155:252-263 (2018). PubMed: 30009768
  • Feng FB & Qiu HY Neuroprotective effect of tanshinone IIA against neuropathic pain in diabetic rats through the Nrf2/ARE and NF-?B signaling pathways. Kaohsiung J Med Sci 34:428-437 (2018). PubMed: 30041760
  • Antognelli C  et al. KRIT1 loss-of-function induces a chronic Nrf2-mediated adaptive homeostasis that sensitizes cells to oxidative stress: Implication for Cerebral Cavernous Malformation disease. Free Radic Biol Med 115:202-218 (2018). PubMed: 29170092
  • Antognelli C  et al. Data in support of sustained upregulation of adaptive redox homeostasis mechanisms caused by KRIT1 loss-of-function. Data Brief 16:929-938 (2018). PubMed: 29511711
  • Arakawa N  et al. Carnosic acid, an inducer of NAD(P)H quinone oxidoreductase 1, enhances the cytotoxicity of ß-lapachone in melanoma cell lines. Oncol Lett 15:2393-2400 (2018). PubMed: 29434949
  • Yu S  et al. NF-E2-related factor 2 serves a key function in resistance to malignant transformation of BEAS-2B cells induced by coal tar pitch. Oncol Lett 15:5143-5148 (2018). PubMed: 29552149
  • Wang L  et al. TIPE-2 suppresses growth and aggressiveness of hepatocellular carcinoma cells through downregulation of the phosphoinositide 3-kinase/AKT signaling pathway. Mol Med Rep 17:7017-7026 (2018). PubMed: 29568863
  • Wang Y  et al. Eicosapentaenoic Acid Improves Polycystic Ovary Syndrome in Rats via Sterol Regulatory Element-Binding Protein 1 (SREBP-1)/Toll-Like Receptor 4 (TLR4) Pathway. Med Sci Monit 24:2091-2097 (2018). PubMed: 29627845
  • Zhang Z  et al. Resolvin D1 promotes corneal epithelial wound healing and restoration of mechanical sensation in diabetic mice. Mol Vis 24:274-285 (2018). PubMed: 29643724
  • Zeng L  et al. A Novel EphA2 Inhibitor Exerts Beneficial Effects in PI-IBS in Vivo and in Vitro Models via Nrf2 and NF-?B Signaling Pathways. Front Pharmacol 9:272 (2018). PubMed: 29662452
  • Nukui A  et al. Clinically significant association of elevated expression of nuclear factor E2-related factor 2 expression with higher glucose uptake and progression of upper urinary tract cancer. BMC Cancer 18:493 (2018). PubMed: 29716554
  • Eskla KL  et al. Hypothermia augments stress response in mammalian cells. Free Radic Biol Med 121:157-168 (2018). WB ; Human . PubMed: 29704622
  • Lv W  et al. Schwann Cell Plasticity is Regulated by a Weakened Intrinsic Antioxidant Defense System in Acute Peripheral Nerve Injury. Neuroscience 382:1-13 (2018). IHC . PubMed: 29684504
  • Ryoo IG  et al. High CD44 expression mediates p62-associated NFE2L2/NRF2 activation in breast cancer stem cell-like cells: Implications for cancer stem cell resistance. Redox Biol 17:246-258 (2018). IHC-P ; Human . PubMed: 29729523
  • Miotto B  et al. Stabilization of the methyl-CpG binding protein ZBTB38 by the deubiquitinase USP9X limits the occurrence and toxicity of oxidative stress in human cells. Nucleic Acids Res 46:4392-4404 (2018). PubMed: 29490077
  • Lisek K  et al. Mutant p53 tunes the NRF2-dependent antioxidant response to support survival of cancer cells. Oncotarget 9:20508-20523 (2018). PubMed: 29755668
  • Xiang Y  et al. Brusatol Enhances the Chemotherapy Efficacy of Gemcitabine in Pancreatic Cancer via the Nrf2 Signalling Pathway. Oxid Med Cell Longev 2018:2360427 (2018). PubMed: 29849873
  • Galiè M  et al. Mild ozonisation activates antioxidant cell response by the Keap1/Nrf2 dependent pathway. Free Radic Biol Med 124:114-121 (2018). ICC/IF ; Human . PubMed: 29864481
  • Zhang C  et al. Nrf2 is a key factor in the reversal effect of curcumin on multidrug resistance in the HCT-8/5-Fu human colorectal cancer cell line. Mol Med Rep 18:5409-5416 (2018). PubMed: 30365132
  • Torrente L  et al. Crosstalk between NRF2 and HIPK2 shapes cytoprotective responses. Oncogene 36:6204-6212 (2017). WB, IP . PubMed: 28692050
  • Wilson MA  et al. skn-1 is required for interneuron sensory integration and foraging behavior in Caenorhabditis elegans. PLoS One 12:e0176798 (2017). PubMed: 28459841
  • Woo Y  et al. Suppression of Nrf2 Activity by Chestnut Leaf Extract Increases Chemosensitivity of Breast Cancer Stem Cells to Paclitaxel. Nutrients 9:N/A (2017). PubMed: 28718813
  • Li X  et al. Myeloid-derived cullin 3 promotes STAT3 phosphorylation by inhibiting OGT expression and protects against intestinal inflammation. J Exp Med 214:1093-1109 (2017). WB, IP ; Mouse . PubMed: 28280036
  • McDonnell C  et al. The Inhibitory Effects of Cobalt Protoporphyrin IX and Cannabinoid 2 Receptor Agonists in Type 2 Diabetic Mice. Int J Mol Sci 18:N/A (2017). WB ; Mouse . PubMed: 29143802
  • Wang L  et al. Allicin Alleviates Reticuloendotheliosis Virus-Induced ImmunosuppressionviaERK/Mitogen-Activated Protein Kinase Pathway in Specific Pathogen-Free Chickens. Front Immunol 8:1856 (2017). PubMed: 29312337
  • Yu C  et al. Metformin Sensitizes Non-small Cell Lung Cancer Cells to an Epigallocatechin-3-Gallate (EGCG) Treatment by Suppressing the Nrf2/HO-1 Signaling Pathway. Int J Biol Sci 13:1560-1569 (2017). PubMed: 29230104
  • Panagaki T  et al. Liraglutide restores chronic ER stress, autophagy impairments and apoptotic signalling in SH-SY5Y cells. Sci Rep 7:16158 (2017). PubMed: 29170452
  • Kubo E  et al. Sulforaphane reactivates cellular antioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress. Sci Rep 7:14130 (2017). PubMed: 29074861
  • Lee D  et al. Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma. J Clin Invest 127:1856-1872 (2017). PubMed: 28394261
  • Skowron MA  et al. Various Mechanisms Involve the Nuclear Factor (Erythroid-Derived 2)-Like (NRF2) to Achieve Cytoprotection in Long-Term Cisplatin-Treated Urothelial Carcinoma Cell Lines. Int J Mol Sci 18:N/A (2017). PubMed: 28767070
  • Chen L  et al. Co-Activation of PKC-d by CRIF1 Modulates Oxidative Stress in Bone Marrow Multipotent Mesenchymal Stromal Cells after Irradiation by Phosphorylating NRF2 Ser40. Theranostics 7:2634-2648 (2017). PubMed: 28819452
  • Yang N  et al. Carnosic acid prevents dextran sulfate sodium-induced acute colitis associated with the regulation of the Keap1/Nrf2 pathway. Sci Rep 7:11036 (2017). PubMed: 28887507
  • Wang Z  et al. Nrf2/HO-1 mediates the neuroprotective effect of mangiferin on early brain injury after subarachnoid hemorrhage by attenuating mitochondria-related apoptosis and neuroinflammation. Sci Rep 7:11883 (2017). PubMed: 28928429
  • Chang Y  et al. Weikangning therapy in functional dyspepsia and the protective role of Nrf2. Exp Ther Med 14:2885-2894 (2017). PubMed: 28928800
  • Karwaciak I  et al. TLR2 activation induces antioxidant defence in human monocyte-macrophage cell line models. Oncotarget 8:54243-54264 (2017). PubMed: 28903338
  • Wang T  et al. Role of Nrf2 signaling pathway in the radiation tolerance of patients with head and neck squamous cell carcinoma: an in vivo and in vitro study. Onco Targets Ther 10:1809-1819 (2017). IHC . PubMed: 28367064
  • Kerr F  et al. Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease. PLoS Genet 13:e1006593 (2017). ICC/IF ; Human . PubMed: 28253260
  • Arai A  et al. p62/SQSTM1 levels predicts radiotherapy resistance in hypopharyngeal carcinomas. Am J Cancer Res 7:881-891 (2017). WB ; Human . PubMed: 28469960
  • Han D  et al. Cytoprotective effect of chlorogenic acid against hydrogen peroxide-induced oxidative stress in MC3T3-E1 cells through PI3K/Akt-mediated Nrf2/HO-1 signaling pathway. Oncotarget 8:14680-14692 (2017). PubMed: 28122344
  • Maj T  et al. Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor. Nat Immunol 18:1332-1341 (2017). WB ; Mouse . PubMed: 29083399
  • Jin X  et al. HO-1/EBP interaction alleviates cholesterol-induced hypoxia through the activation of the AKT and Nrf2/mTOR pathways and inhibition of carbohydrate metabolism in cardiomyocytes. Int J Mol Med 39:1409-1420 (2017). PubMed: 28487965
  • Jiang X  et al. VPS34 stimulation of p62 phosphorylation for cancer progression. Oncogene 36:6850-6862 (2017). PubMed: 28846113
  • Scott DC  et al. Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase. Nat Chem Biol 13:850-857 (2017). PubMed: 28581483
  • Jin X  et al. HO-1 alleviates cholesterol-induced oxidative stress through activation of Nrf2/ERK and inhibition of PI3K/AKT pathways in endothelial cells. Mol Med Rep 16:3519-3527 (2017). PubMed: 28713890
  • Tan EP  et al. Sustained O-GlcNAcylation reprograms mitochondrial function to regulate energy metabolism. J Biol Chem 292:14940-14962 (2017). PubMed: 28739801
  • Sun X  et al. NOX4- and Nrf2-mediated oxidative stress induced by silver nanoparticles in vascular endothelial cells. J Appl Toxicol 37:1428-1437 (2017). PubMed: 28815642
  • Bao L  et al. ABCF2, an Nrf2 target gene, contributes to cisplatin resistance in ovarian cancer cells. Mol Carcinog 56:1543-1553 (2017). PubMed: 28112439
  • Lu K  et al. NRF2 Induction Supporting Breast Cancer Cell Survival Is Enabled by Oxidative Stress-Induced DPP3-KEAP1 Interaction. Cancer Res 77:2881-2892 (2017). PubMed: 28416489
  • Olagnier D  et al. Activation of Nrf2 Signaling Augments Vesicular Stomatitis Virus Oncolysis via Autophagy-Driven Suppression of Antiviral Immunity. Mol Ther 25:1900-1916 (2017). PubMed: 28527723
  • Chigusa Y  et al. Nrf2 Activation Inhibits Effects of Thrombin in Human Amnion Cells and Thrombin-Induced Preterm Birth in Mice. J Clin Endocrinol Metab 101:2612-21 (2016). PubMed: 27050800
  • Guntas G  et al. Engineering a genetically encoded competitive inhibitor of the KEAP1-NRF2 interaction via structure-based design and phage display. Protein Eng Des Sel 29:1-9 (2016). PubMed: 26489878
  • Sun X  et al. Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells. Hepatology 63:173-84 (2016). PubMed: 26403645
  • Sun X  et al. Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis. Hepatology 64:488-500 (2016). PubMed: 27015352
  • Ogunbileje JO  et al. Hypermetabolism and hypercatabolism of skeletal muscle accompany mitochondrial stress following severe burn trauma. Am J Physiol Endocrinol Metab 311:E436-48 (2016). PubMed: 27382037
  • Ildefonso CJ  et al. Targeting the Nrf2 Signaling Pathway in the Retina With a Gene-Delivered Secretable and Cell-Penetrating Peptide. Invest Ophthalmol Vis Sci 57:372-86 (2016). PubMed: 26842755
  • Goldstein LD  et al. Recurrent Loss of NFE2L2 Exon 2 Is a Mechanism for Nrf2 Pathway Activation in Human Cancers. Cell Rep 16:2605-2617 (2016). PubMed: 27568559
  • Ingersoll MA  et al. Statin derivatives as therapeutic agents for castration-resistant prostate cancer. Cancer Lett 383:94-105 (2016). PubMed: 27687622
  • Tian Y  et al. Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer. J Hematol Oncol 9:83 (2016). PubMed: 27601007
  • Spriggs S  et al. Effect of Repeated Daily Dosing with 2,4-Dinitrochlorobenzene on Glutathione Biosynthesis and Nrf2 Activation in Reconstructed Human Epidermis. Toxicol Sci 154:5-15 (2016). PubMed: 27492222
  • Latham Birt SH  et al. Endothelial HO-1 induction by model TG-rich lipoproteins is regulated through a NOX4-Nrf2 pathway. J Lipid Res 57:1204-18 (2016). PubMed: 27185859
  • Comerford SA  et al. Hepatoblastoma modeling in mice places Nrf2 within a cancer field established by mutant ß-catenin. JCI Insight 1:e88549 (2016). WB ; Human . PubMed: 27734029
  • Pan H  et al. SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2. Cell Res 26:190-205 (2016). WB, ChIP ; Human . PubMed: 26768768
  • Wu ST  et al. Cellular effects induced by 17-ß-estradiol to reduce the survival of renal cell carcinoma cells. J Biomed Sci 23:67 (2016). WB ; Human . PubMed: 27680214
  • Zhang C  et al. NRF2 promotes breast cancer cell proliferation and metastasis by increasing RhoA/ROCK pathway signal transduction. Oncotarget 7:73593-73606 (2016). ChIP ; Human . PubMed: 27713154
  • Schumacher FR  et al. RNAi Screen for NRF2 Inducers Identifies Targets That Rescue Primary Lung Epithelial Cells from Cigarette Smoke Induced Radical Stress. PLoS One 11:e0166352 (2016). WB ; Human . PubMed: 27832175
  • Gendron JM  et al. Using the Ubiquitin-modified Proteome to Monitor Distinct and Spatially Restricted Protein Homeostasis Dysfunction. Mol Cell Proteomics 15:2576-93 (2016). PubMed: 27185884
  • Zhang X  et al. Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers. Nat Genet 48:176-82 (2016). PubMed: 26656844
  • Lien EC  et al. Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer. Nat Cell Biol 18:572-8 (2016). PubMed: 27088857
  • de la Ballina LR  et al. Amino Acid Transport Associated to Cluster of Differentiation 98 Heavy Chain (CD98hc) Is at the Cross-road of Oxidative Stress and Amino Acid Availability. J Biol Chem 291:9700-11 (2016). PubMed: 26945935
  • Shen C  et al. Resveratrol pretreatment attenuates injury and promotes proliferation of neural stem cells following oxygen-glucose deprivation/reoxygenation by upregulating the expression of Nrf2, HO-1 and NQO1 in vitro. Mol Med Rep 14:3646-54 (2016). WB . PubMed: 27573874
  • Vartanian S  et al. Application of Mass Spectrometry Profiling to Establish Brusatol as an Inhibitor of Global Protein Synthesis. Mol Cell Proteomics 15:1220-31 (2016). PubMed: 26711467
  • Shah JJ  et al. Phase I Study of the Novel Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (MLN4924) in Patients with Relapsed/Refractory Multiple Myeloma or Lymphoma. Clin Cancer Res 22:34-43 (2016). PubMed: 26561559
  • Caro AA  et al. Prooxidant and antioxidant properties of salicylaldehyde isonicotinoyl hydrazone iron chelators in HepG2 cells. Biochim Biophys Acta 1850:2256-64 (2015). PubMed: 26275495
  • Jiang M  et al. BMP-driven NRF2 activation in esophageal basal cell differentiation and eosinophilic esophagitis. J Clin Invest 125:1557-68 (2015). PubMed: 25774506
  • Sachweh MC  et al. Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells. Oncotarget 6:16488-506 (2015). WB . PubMed: 26029997
  • Bakkar N  et al. RBM45 Modulates the Antioxidant Response in Amyotrophic Lateral Sclerosis through Interactions with KEAP1. Mol Cell Biol 35:2385-99 (2015). PubMed: 25939382
  • Liu K  et al. NQO1 Stabilizes p53 in Response to Oncogene-Induced Senescence. Int J Biol Sci 11:762-71 (2015). WB, ChIP . PubMed: 26078718
  • Kemmerer ZA  et al. Comparison of human Nrf2 antibodies: A tale of two proteins. Toxicol Lett 238:83-9 (2015). PubMed: 26220517
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