Overview

  • Product name

    Anti-NRL antibody
  • Description

    Rabbit polyclonal to NRL
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide corresponding to the N terminal region of Human NRL (UniProt P54845).

  • Positive control

    • HUVEC cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab137193 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 26 kDa.

Target

  • Function

    Transcription factor which regulates the expression of several rod-specific genes, in cluding RHO and PDE6B.
  • Tissue specificity

    Neural retina.
  • Involvement in disease

    Defects in NRL are the cause of retinitis pigmentosa type 27 (RP27) [MIM:162080]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP27 inheritance is autosomal dominant.
  • Sequence similarities

    Belongs to the bZIP family.
    Contains 1 bZIP domain.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • D14S46E antibody
    • Neural retina-specific leucine zipper protein antibody
    • Neural retinal specific leucine zipper antibody
    • NRL antibody
    • NRL MAF antibody
    • NRL_HUMAN antibody
    • RP27 antibody
    see all

Images

  • Anti-NRL antibody (ab137193) at 1/500 dilution + HUVEC cell lysate at 30 µg

    Predicted band size: 26 kDa

References

This product has been referenced in:

  • Jamshidi F  et al. Contribution of noncoding pathogenic variants to RPGRIP1-mediated inherited retinal degeneration. Genet Med 21:694-704 (2019). Read more (PubMed: 30072743) »
See 1 Publication for this product

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