Key features and details
- Potent and selective KCa1.1 channel activator
- CAS Number: 153587-01-0
- Purity: > 98%
- Soluble in ethanol to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameNS 1619, KCa1.1 channel activator
DescriptionPotent and selective KCa1.1 channel activator
Potent and selective KCa1.1 channel activator. Induces a concentration-dependent decrease in mitochondrial membrane potential (EC50 = 3.6 μM).
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in ethanol to 100 mM and in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
NS-1619 blocks KCa1.1 currents in Xenopus oocytes.
A. Families of KCa1.1 channel current responses to increasing voltage step stimulation (from -50 mV to + 50 mV), before (left) and during (right) application of 100 µM NS-1619 (ab141824). Currents were elicited by 100 ms voltage step from -100mV applied every 10 sec. B. Time course of current amplitude at 0 mV before, during application of 100 µM NS-1619 (green) and upon wash, demonstrating the current amplitude enhancement. C. Voltage dependence of KCa1.1 channel activity enhancement.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab141824 has been referenced in 2 publications.
- Zhou Y et al. Topology-dependent, bifurcated mitochondrial quality control under starvation. Autophagy 16:562-574 (2020). PubMed: 31234709
- Wang M et al. Regulation of Spontaneous Contractions in Intact Rat Bladder Strips and the Effects of Hydrogen Peroxide. Biomed Res Int 2018:2925985 (2018). PubMed: 29511675