Overview

  • Product name

    NS-1643, HERG (Kv11.1) channel activator
  • Description

    HERG (Kv11.1) channel activator
  • Biological description

    HERG (Kv11.1) channel activator (EC50 = 10.5 μM). Increases erg2 (Kv11.2) currents. Displays antiarrhythmic activity in vitro.
  • Purity

    > 95%
  • CAS Number

    448895-37-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1,3-Bis[2-hydroxy-5-(trifluoromethyl)phenyl]urea
  • Molecular weight

    380.20
  • Molecular formula

    C15H10F6N2O3
  • PubChem identifier

    10177784
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 100 mM and in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC(=C(C=C1C(F)(F)F)NC(=O)NC2=C(C=CC(=C2)C(F)(F)F)O)O
  • Source

    Synthetic

  • Research areas

Images

  • NS-1643 enhances KV11.1 (hERG) currents in Xenopus oocytes.

    A. Time course of current amplitude at -40 mV (see B for the voltage stimulating protocol) before, during application of 10 and 30 µM NS-1643 (ab141825) (indicated by bars) and upon wash, demonstrating the current amplitude enhancement. B. Superimposed example traces of KV11.1 channel current responses, before and during application of 10 and 30 µM NS-1643. Currents were elicited by 500 ms voltage step from -100mV to -10 mV followed by a 200 ms step to -40 mV (demonstrated on top) , applied every 10 sec.

References

This product has been referenced in:

  • Bilet A & Bauer CK Effects of the small molecule HERG activator NS1643 on Kv11.3 channels. PLoS One 7:e50886 (2012). Read more (PubMed: 23226420) »
  • Grunnet M  et al. Molecular determinants of human ether-à-go-go-related gene 1 (hERG1) K+ channel activation by NS1643. Mol Pharmacol 79:1-9 (2011). Read more (PubMed: 20876384) »
  • Schuster AM  et al. Strong activation of ether-à-go-go-related gene 1 K+ channel isoforms by NS1643 in human embryonic kidney 293 and Chinese hamster ovary cells. Mol Pharmacol 80:930-42 (2011). Read more (PubMed: 21856740) »
See 1 Publication for this product

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