Overview

  • Product name

    NSC 23766 trihydrochloride, Rac-1 inhibitor
  • Description

    Selective Rac-1 inhibitor
  • Biological description

    Selective Rac-1 inhibitor. Blocks Rac-specific guanine nucleotide exchange factors TrioN and Tiam1 (IC50 = 50 μM) without affecting Cdc42 or RhoA activation. Apoptotic and causes G1 cell cycle arrest in vitro. Cell-permeable. Active in vivo and centrally active.
  • Purity

    > 98%
  • CAS Number

    1177865-17-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrochloride
  • Molecular weight

    530.97
  • Molecular formula

    C24H35N7.3HCl
  • PubChem identifier

    16759159
  • Storage instructions

    Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCN(CC)CCCC(C)NC1=NC(=CC(=N1)NC2=CC3=C(C=C2)N=C(C=C3N)C)C.Cl.Cl.Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Yao HY  et al. Inhibition of Rac activity alleviates lipopolysaccharide-induced acute pulmonary injury in mice. Biochim Biophys Acta 1810:666-74 (2011). Read more (PubMed: 21511011) »
  • Yoshida T  et al. Blockade of Rac1 activity induces G1 cell cycle arrest or apoptosis in breast cancer cells through downregulation of cyclin D1, survivin, and X-linked inhibitor of apoptosis protein. Mol Cancer Ther 9:1657-68 (2010). Read more (PubMed: 20515940) »
  • Hable WE  et al. The Rac1 inhibitor, NSC23766, depolarizes adhesive secretion, endomembrane cycling, and tip growth in the fucoid alga, Silvetia compressa. Planta 227:991-1000 (2008). Read more (PubMed: 18183417) »
  • Tan AM  et al. Neuropathic pain memory is maintained by Rac1-regulated dendritic spine remodeling after spinal cord injury. J Neurosci 28:13173-83 (2008). Read more (PubMed: 19052208) »
  • Gao Y  et al. Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proc Natl Acad Sci U S A 101:7618-23 (2004). Read more (PubMed: 15128949) »

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