NSC 319726, p53(R175) mutant reactivator (ab145843)

Overview

  • Product name

    NSC 319726, p53(R175) mutant reactivator
  • Description

    Selective p53(R175) mutant reactivator
  • Alternative names

    • 1-Azetidinecarbothioic acid [1-(2-pyridinyl)ethylidene]hydrazide
    • NSC319726
    • ZMC1
  • Biological description

    p53(R175) mutant reactivator. Inhibits growth of fibroblasts expressing the p53(R175) mutation (IC50 = 8 nM), shows no inhibition for p53 wild-type cells. Displays 10- to 100-fold selectivity over the other hotspot p53 mutants and induces p53(R175)-mutant-dependent apoptosis. Also inhibits growth of xenograft tumors expressing the p53(R175) mutation in vivo. Restores p53 wild-type structure by functioning as a zinc-metallochaperone.

  • Purity

    > 95%
  • CAS Number

    71555-25-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-[(E)-1-Pyridin-2-ylethylideneamino]azetidine-1-carbothioamide
  • Molecular weight

    234.32
  • Molecular formula

    C11H14N4S
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 75 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

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