Overview

  • Product name

  • Description

    Rabbit polyclonal to NSFL1C
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human NSFL1C aa 1-185.
    Database link: Q9UNZ2

  • Positive control

    • IHC-P: Human testis and lung cancer tissues.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: PBS, 50% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab234785 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/200.

Target

  • Function

    Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro).
  • Sequence similarities

    Belongs to the NSFL1C family.
    Contains 1 SEP domain.
    Contains 1 UBX domain.
  • Post-translational
    modifications

    Phosphorylated during mitosis. Phosphorylation inhibits interaction with Golgi membranes and is required for the fragmentation of the Golgi stacks during mitosis.
  • Cellular localization

    Nucleus. Golgi apparatus > Golgi stack. Chromosome. Predominantly nuclear in interphase cells. Bound to the axial elements of sex chromosomes in pachytene spermatocytes. A small proportion of the protein is cytoplasmic, associated with Golgi stacks.
  • Information by UniProt
  • Database links

  • Alternative names

    • DJ776F14.1 antibody
    • MGC3347 antibody
    • NSF1C_HUMAN antibody
    • NSFL1 (p97) cofactor (p47) antibody
    • NSFL1 cofactor p47 antibody
    • NSFL1C antibody
    • OTTHUMP00000029972 antibody
    • OTTHUMP00000029974 antibody
    • p47 antibody
    • P47 protein antibody
    • p97 cofactor p47 antibody
    • SHP1 homolog antibody
    • UBX domain protein 2C antibody
    • UBX domain-containing protein 2C antibody
    • UBX1 antibody
    • UBXD10 antibody
    • UBXN2C antibody
    see all

Images

  • Paraffin-embedded human testis tissue stained for NSFL1C using ab234785 at 1/100 dilution in immunohistochemical analysis.

  • Paraffin-embedded human lung cancer tissue stained for NSFL1C using ab234785 at 1/100 dilution in immunohistochemical analysis.

References

ab234785 has not yet been referenced specifically in any publications.

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There are currently no Customer reviews or Questions for ab234785.
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