Anti-NSMase2 antibody (ab172793)
Key features and details
- Rabbit polyclonal to NSMase2
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-NSMase2 antibody
See all NSMase2 primary antibodies -
Description
Rabbit polyclonal to NSMase2 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant full length protein corresponding to Human NSMase2 aa 1-655. (NP_061137.1).
Sequence:MVLYTTPFPNSCLSALHCVSWALIFPCYWLVDRLAASFIPTTYEKRQRAD DPCCLQLLCTALFTPIYLALLVASLPFAFLGFLFWSPLQSARRPYIYSRL EDKGLAGGAALLSEWKGTGPGKSFCFATANVCLLPDSLARVNNLFNTQAR AKEIGQRIRNGAARPQIKIYIDSPTNTSISAASFSSLVSPQGGDGVARAV PGSIKRTASVEYKGDGGRHPGDEAANGPASGDPVDSSSPEDACIVRIGGE EGGRPPEADDPVPGGQARNGAGGGPRGQTPNHNQQDGDSGSLGSPSASRE SLVKGRAGPDTSASGEPGANSKLLYKASVVKKAAARRRRHPDEAFDHEVS AFFPANLDFLCLQEVFDKRAATKLKEQLHGYFEYILYDVGVYGCQGCCSF KCLNSGLLFASRYPIMDVAYHCYPNKCNDDALASKGALFLKVQVGSTPQD QRIVGYIACTHLHAPQEDSAIRCGQLDLLQDWLADFRKSTSSSSAANPEE LVAFDVVCGDFNFDNCSSDDKLEQQHSLFTHYRDPCRLGPGEEKPWAIGT LLDTNGLYDEDVCTPDNLQKVLESEEGRREYLAFPTSKSSGQKGRKELLK GNGRRIDYMLHAEEGLCPDWKAEVEEFSFITQLSGLTDHLPVAMRLMVSS GEEEA
Database link: Q9NY59 -
Positive control
- NSMase2 transfected 293T cell line lysate
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.4
Constituent: 100% PBS -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
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Related Products
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab172793 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Use a concentration of 1 µg/ml. Predicted molecular weight: 71 kDa.
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Notes |
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WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 71 kDa. |
Target
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Function
Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization. -
Tissue specificity
Predominantly expressed in brain. -
Sequence similarities
Belongs to the neutral sphingomyelinase family. -
Developmental stage
Up-regulated during G0/G1 phases. -
Cellular localization
Golgi apparatus membrane. Cell membrane. May localize to detergent-resistant subdomains of Golgi membranes of hypothalamic neurosecretory neurons. According to PubMed:15051724, it localizes to plasma membrane in confluent contact-inhibited cells. - Information by UniProt
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Database links
- Entrez Gene: 55512 Human
- Omim: 605777 Human
- SwissProt: Q9NY59 Human
- Unigene: 368421 Human
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Alternative names
- Cca1 antibody
- Confluent 3Y1 cell-associated protein 1 antibody
- Neutral sphingomyelinase 2 antibody
see all
Images
Datasheets and documents
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Datasheet download
References (0)
ab172793 has not yet been referenced specifically in any publications.