Overview

  • Product name

  • Description

    Rabbit polyclonal to NSUN2/SAKI
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, ELISA, IHC-Frmore details
  • Species reactivity

    Reacts with: Mouse
    Predicted to work with: Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Mouse NSUN2/SAKI (internal sequence).

  • General notes

     This product was previously labelled as NSUN2

     

Properties

Applications

Our Abpromise guarantee covers the use of ab128243 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/5000. Predicted molecular weight: 85 kDa.
ELISA Use at an assay dependent concentration.
IHC-Fr 1/100 - 1/1000.

Target

  • Function

    RNA methyltransferase that methylates tRNAs, and possibly RNA polymerase III transcripts. Methylates cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. Not able to modify tRNAs at positions 48 or 49. May act downstream of Myc to regulate epidermal cell growth and proliferation.
  • Sequence similarities

    Belongs to the methyltransferase superfamily. RsmB/NOP family. TRM4 subfamily.
  • Post-translational
    modifications

    Phosphorylated at Ser-139 by Aurora-B/STK12 during mitosis, leading to abolish methyltransferase activity and the interaction with NPM1.
  • Cellular localization

    Nucleus > nucleolus. Cytoplasm. Concentrated in the nucleolus during interphase and distributed in the perichromosome and cytoplasm during mitosis.
  • Information by UniProt
  • Database links

  • Alternative names

    • 5 methycytoisine methyltransferase antibody
    • D13Wsu123e antibody
    • FLJ20303 antibody
    • hTrm4 antibody
    • MISU antibody
    • Myc induced SUN domain containing protein antibody
    • NOL1/NOP2/Sun domain family 2 antibody
    • NOL1/NOP2/Sun domain family 2 protein antibody
    • NOL1/NOP2/Sun domain family member 2 antibody
    • NSUN 2 antibody
    • NSUN2 antibody
    • NSUN2_HUMAN antibody
    • SAKI antibody
    • Substrate of AIM1/Aurora kinase B antibody
    • TRM4 antibody
    • tRNA (cytosine 5 ) methyltransferase antibody
    • tRNA (cytosine 5 ) methyltransferase NSUN2 antibody
    • tRNA (cytosine(34)-C(5))-methyltransferase antibody
    • tRNA (cytosine-5-)-methyltransferase antibody
    • tRNA methyltransferase 4 homolo antibody
    • tRNA methyltransferase 4 homolog antibody
    see all

References

ab128243 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab128243.
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