Recombinant
Recombinant Anti-NT-4 antibody [EPR9180] (ab150437)
- Datasheet
- References
- Protocols
Overview
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Product name
Anti-NT-4 antibody [EPR9180]
See all NT-4 primary antibodies -
Description
Rabbit monoclonal [EPR9180] to NT-4 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details
Unsuitable for: ICC/IF,IHC-P or IP -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat
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Immunogen
Synthetic peptide within Human NT-4 aa 50-150. The exact sequence is proprietary.
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Positive control
- Human prostate cancer tissue lysate, Human stomach tissue lysate
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General notes
Previously labelled as Neurotrophin 4.
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.
This product is a recombinant rabbit monoclonal antibody.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol, 0.05% BSA, 50% Tissue culture supernatant -
Purity
Tissue culture supernatant -
Clonality
Monoclonal -
Clone number
EPR9180 -
Isotype
IgG -
Research areas
Associated products
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Alternative Versions
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Isotype control
Applications
Our Abpromise guarantee covers the use of ab150437 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB | 1/1000 - 1/10000. Predicted molecular weight: 22 kDa. |
Application notes
Is unsuitable for ICC/IF,IHC-P or IP.
Target
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Function
Target-derived survival factor for peripheral sensory sympathetic neurons. -
Tissue specificity
Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed in embryonic and adult tissues. -
Involvement in disease
Defects in NTF4 may be associated with susceptibility to primary open angle glaucoma type 1O (GLC1O) [MIM:613100]. A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. -
Sequence similarities
Belongs to the NGF-beta family. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 4909 Human
- Entrez Gene: 78405 Mouse
- Entrez Gene: 25730 Rat
- Omim: 162662 Human
- SwissProt: P34130 Human
- SwissProt: Q80VU4 Mouse
- SwissProt: P34131 Rat
- Unigene: 266902 Human
see all -
Alternative names
- GLC10 antibody
- GLC1O antibody
- Neurotrophic factor 4 antibody
see all
Images
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![Western blot - Anti-NT-4 antibody [EPR9180] (ab150437)](https://www.abcam.com/ps/products/150/ab150437/Images/Neurotrophin-4-Primary-antibodies-ab150437-1.jpg)
Western blot - Anti-NT-4 antibody [EPR9180] (ab150437)All lanes : Anti-NT-4 antibody [EPR9180] (ab150437) at 1/1000 dilution
Lane 1 : Human prostate cancer tissue lysate
Lane 2 : Human stomach tissue lysate
Lysates/proteins at 10 µg per lane.
Secondary
All lanes : Goat anti-rabbit HRP labelled antibody at 1/2000 dilution
Predicted band size: 22 kDa
Protocols
Datasheets and documents
References
ab150437 has not yet been referenced specifically in any publications.
