Overview

  • Product name

  • Description

    Rabbit polyclonal to NTAL
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Fusion protein corresponding to Human NTAL (internal sequence). (BC001609).
    Database link: Q9GZY6

  • Positive control

    • Human colon cancer tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab197664 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/10 - 1/50.

Target

  • Function

    Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.
  • Tissue specificity

    Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level).
  • Involvement in disease

    Note=LAT2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of LAT2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
  • Post-translational
    modifications

    Phosphorylated on tyrosines following cross-linking of BCR in B-cells, FCGR1 in myeloid cells, or FCER1 in mast cells; which induces the recruitment of GRB2.
    May be polyubiquitinated.
  • Cellular localization

    Cell membrane. Present in lipid rafts.
  • Information by UniProt
  • Database links

  • Alternative names

    • HSPC046 antibody
    • LAB antibody
    • LAT2 antibody
    • Linker for activation of B cells antibody
    • Linker for activation of B-cells antibody
    • Linker for activation of T cells family member 2 antibody
    • Linker for activation of T cells transmembrane adaptor 2 antibody
    • Linker for activation of T-cells family member 2 antibody
    • Membrane associated adapter molecule antibody
    • Membrane-associated adapter molecule antibody
    • Non T cell activation linker antibody
    • Non-T-cell activation linker antibody
    • NTAL_HUMAN antibody
    • WBSCR 5 antibody
    • Wbscr15 antibody
    • Williams Beuren syndrome chromosome region 15 antibody
    • Williams Beuren syndrome chromosome region 5 antibody
    • Williams-Beuren syndrome chromosomal region 15 protein antibody
    • Williams-Beuren syndrome chromosomal region 5 protein antibody
    • WSCR5 antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue labeling NTAL with ab197664 at 1/15 dilution.

References

This product has been referenced in:

  • Posey KL  et al. Chondrocyte-specific pathology during skeletal growth and therapeutics in a murine model of pseudoachondroplasia. J Bone Miner Res 29:1258-68 (2014). Read more (PubMed: 24194321) »
See 1 Publication for this product

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