Anti-Nucleophosmin antibody [FC82291] (ab10530)

Mouse monoclonal Nucleophosmin antibody [FC82291]. Validated in WB, IP, ELISA, IHC, ICC/IF and tested in Mouse, Rat, Donkey, Hamster, Cow, Dog, Human, African green monkey. Cited in 54 publication(s).

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ab10530 has been referenced in 58 publications.

  • Liu Y  et al. Maternal DCAF13 Regulates Chromatin Tightness to Contribute to Embryonic Development. Sci Rep 9:6278 (2019). PubMed: 31000741
  • Yehia L  et al. Non-canonical role of cancer-associated mutant SEC23B in the ribosome biogenesis pathway. Hum Mol Genet 27:3154-3164 (2018). PubMed: 29893852
  • Bonora G  et al. Orientation-dependent Dxz4 contacts shape the 3D structure of the inactive X chromosome. Nat Commun 9:1445 (2018). PubMed: 29654302
  • Krastev DB  et al. Coupling bimolecular PARylation biosensors with genetic screens to identify PARylation targets. Nat Commun 9:2016 (2018). PubMed: 29789535
  • Rosinska S & Filipek A Interaction of CacyBP/SIP with NPM1 and its influence on NPM1 localization and function in oxidative stress. J Cell Physiol N/A:N/A (2018). PubMed: 29806702
  • Dumbovic G  et al. A novel long non-coding RNA from NBL2 pericentromeric macrosatellite forms a perinucleolar aggregate structure in colon cancer. Nucleic Acids Res 46:5504-5524 (2018). PubMed: 29912433
  • Mata-Garrido J  et al. Persistent accumulation of unrepaired DNA damage in rat cortical neurons: nuclear organization and ChIP-seq analysis of damaged DNA. Acta Neuropathol Commun 6:68 (2018). PubMed: 30049290
  • Kim YE  et al. Quantitative Proteomic Analysis of 2D and 3D Cultured Colorectal Cancer Cells: Profiling of Tankyrase Inhibitor XAV939-Induced Proteome. Sci Rep 8:13255 (2018). PubMed: 30185973
  • Froberg JE  et al. Megadomains and superloops form dynamically but are dispensable for X-chromosome inactivation and gene escape. Nat Commun 9:5004 (2018). PubMed: 30479398
  • Posavec Marjanovic M  et al. MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD+ consumption. Nat Struct Mol Biol 24:902-910 (2017). PubMed: 28991266
  • Mizielinska S  et al. Bidirectional nucleolar dysfunction in C9orf72 frontotemporal lobar degeneration. Acta Neuropathol Commun 5:29 (2017). PubMed: 28420437
  • Ando K  et al. NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus. J Cell Biol 216:1795-1810 (2017). PubMed: 28432080
  • Douet J  et al. MacroH2A histone variants maintain nuclear organization and heterochromatin architecture. J Cell Sci 130:1570-1582 (2017). PubMed: 28283545
  • Ye Q  et al. Therapeutic Targeting of RNA Polymerase I With the Small-Molecule CX-5461 for Prevention of Arterial Injury-Induced Neointimal Hyperplasia. Arterioscler Thromb Vasc Biol 37:476-484 (2017). PubMed: 28062495
  • Cheung DH  et al. Nucleophosmin Interacts with PIN2/TERF1-interacting Telomerase Inhibitor 1 (PinX1) and Attenuates the PinX1 Inhibition on Telomerase Activity. Sci Rep 7:43650 (2017). IF . PubMed: 28255170
  • Chitale S & Richly H Nuclear organization of nucleotide excision repair is mediated by RING1B dependent H2A-ubiquitylation. Oncotarget 8:30870-30887 (2017). PubMed: 28416769
  • Huang M  et al. Autophagy mediates proteolysis of NPM1 and HEXIM1 and sensitivity to BET inhibition in AML cells. Oncotarget 7:74917-74930 (2016). WB ; Human . PubMed: 27732946
  • Destouches D  et al. Implication of NPM1 phosphorylation and preclinical evaluation of the nucleoprotein antagonist N6L in prostate cancer. Oncotarget 7:69397-69411 (2016). PubMed: 26993766
  • Shorbagi S & Brown IR Dynamics of the association of heat shock protein HSPA6 (Hsp70B') and HSPA1A (Hsp70-1) with stress-sensitive cytoplasmic and nuclear structures in differentiated human neuronal cells. Cell Stress Chaperones 21:993-1003 (2016). PubMed: 27527722
  • Vickers TA & Crooke ST Development of a Quantitative BRET Affinity Assay for Nucleic Acid-Protein Interactions. PLoS One 11:e0161930 (2016). WB . PubMed: 27571227
  • Garcia JS  et al. Selective Toxicity of Investigational Ixazomib for Human Leukemia Cells Expressing Mutant Cytoplasmic NPM1: Role of Reactive Oxygen Species. Clin Cancer Res 22:1978-88 (2016). PubMed: 26634271
  • Jørgensen MM  et al. Potentials and capabilities of the Extracellular Vesicle (EV) Array. J Extracell Vesicles 4:26048 (2015). PubMed: 25862471
  • Tancioni I  et al. FAK activity protects nucleostemin in facilitating breast cancer spheroid and tumor growth. Breast Cancer Res 17:47 (2015). PubMed: 25880415
  • Arnoldo L  et al. A novel mechanism of post-translational modulation of HMGA functions by the histone chaperone nucleophosmin. Sci Rep 5:8552 (2015). WB . PubMed: 25711412
  • Nouri K  et al. Biophysical Characterization of Nucleophosmin Interactions with Human Immunodeficiency Virus Rev and Herpes Simplex Virus US11. PLoS One 10:e0143634 (2015). PubMed: 26624888
  • Ponti D  et al. The expression of B23 and EGR1 proteins is functionally linked in tumor cells under stress conditions. BMC Cell Biol 16:27 (2015). WB . PubMed: 26577150
  • Wang L  et al. Intracellular CD24 disrupts the ARF-NPM interaction and enables mutational and viral oncogene-mediated p53 inactivation. Nat Commun 6:5909 (2015). PubMed: 25600590
  • Qi R  et al. The lamin-A/C-LAP2a-BAF1 protein complex regulates mitotic spindle assembly and positioning. J Cell Sci 128:2830-41 (2015). PubMed: 26092935
  • Hamilton G  et al. AKT regulates NPM dependent ARF localization and p53mut stability in tumors. Oncotarget 5:6142-67 (2014). PubMed: 25071014
  • Lührig S  et al. Lrrc34, a novel nucleolar protein, interacts with npm1 and ncl and has an impact on pluripotent stem cells. Stem Cells Dev 23:2862-74 (2014). PubMed: 24991885
  • Goudarzi KM  et al. mTOR inhibitors blunt the p53 response to nucleolar stress by regulating RPL11 and MDM2 levels. Cancer Biol Ther 15:1499-514 (2014). Human . PubMed: 25482947
  • Taha MS  et al. Subcellular fractionation and localization studies reveal a direct interaction of the fragile X mental retardation protein (FMRP) with nucleolin. PLoS One 9:e91465 (2014). ICC/IF ; Human . PubMed: 24658146
  • Ponti D  et al. The transcription factor EGR1 localizes to the nucleolus and is linked to suppression of ribosomal precursor synthesis. PLoS One 9:e96037 (2014). WB ; Human . PubMed: 24787739
  • Paciaroni K  et al. Transfusion-independent ß(0)-thalassemia after bone marrow transplantation failure: proposed involvement of high parental HbF and an epigenetic mechanism. Am J Blood Res 4:27-32 (2014). WB ; Human . PubMed: 25232502
  • Khalouei S  et al. Localization of heat shock protein HSPA6 (HSP70B') to sites of transcription in cultured differentiated human neuronal cells following thermal stress. J Neurochem 131:743-54 (2014). PubMed: 25319762
  • Ding A  et al. Impact of NPM, TFF3 and TACC1 on the prognosis of patients with primary gastric cancer. PLoS One 8:e82136 (2013). IHC-P ; Human . PubMed: 24358147
  • Cong R  et al. macroH2A1 histone variant represses rDNA transcription. Nucleic Acids Res N/A:N/A (2013). PubMed: 24071584
  • Figeac N  et al. ErbB3 binding protein-1 (Ebp1) controls proliferation and myogenic differentiation of muscle stem cells. Dev Biol N/A:N/A (2013). ICC/IF ; Mouse . PubMed: 24275324
  • Bennetzen MV  et al. Acetylation dynamics of human nuclear proteins during the ionizing radiation-induced DNA damage response. Cell Cycle 12:1688-95 (2013). PubMed: 23656789
  • Lam L  et al. Regulation of subcellular distribution and oncogenic potential of nucleophosmin by plakoglobin. Oncogenesis 1:e4 (2012). PubMed: 23552556
  • Ferrando IM  et al. Identification of targets of c-Src tyrosine kinase by chemical complementation and phosphoproteomics. Mol Cell Proteomics 11:355-69 (2012). WB . PubMed: 22499769
  • Kalt I  et al. Nucleolar localization of GLTSCR2/PICT-1 is mediated by multiple unique nucleolar localization sequences. PLoS One 7:e30825 (2012). PubMed: 22292050
  • Cong R  et al. Interaction of nucleolin with ribosomal RNA genes and its role in RNA polymerase I transcription. Nucleic Acids Res 40:9441-54 (2012). PubMed: 22859736
  • Papadopoulos P  et al. A dual reporter mouse model of the human ß-globin locus: applications and limitations. PLoS One 7:e51272 (2012). WB ; Mouse . PubMed: 23272095
  • Hu R  et al. ZNF668 functions as a tumor suppressor by regulating p53 stability and function in breast cancer. Cancer Res 71:6524-34 (2011). PubMed: 21852383
  • Benedikt A  et al. The leukemogenic AF4-MLL fusion protein causes P-TEFb kinase activation and altered epigenetic signatures. Leukemia 25:135-44 (2011). WB, IP ; Human . PubMed: 21030982
  • Gallenberger M  et al. Lack of WDR36 leads to preimplantation embryonic lethality in mice and delays the formation of small subunit ribosomal RNA in human cells in vitro. Hum Mol Genet 20:422-35 (2011). ICC/IF ; Human . PubMed: 21051332
  • Doukhanine E  et al. The QKI-6 RNA binding protein regulates actin-interacting protein-1 mRNA stability during oligodendrocyte differentiation. Mol Biol Cell 21:3029-40 (2010). WB ; Human . PubMed: 20631256
  • Borg J  et al. Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin. Nat Genet 42:801-5 (2010). WB ; Human . PubMed: 20676099
  • Bandhakavi S  et al. Quantitative nuclear proteomics identifies mTOR regulation of DNA damage response. Mol Cell Proteomics 9:403-14 (2010). PubMed: 19955088
  • Johansson H & Simonsson S Core transcription factors, Oct4, Sox2 and Nanog, individually form complexes with nucleophosmin (Npm1) to control embryonic stem (ES) cell fate determination. Aging (Albany NY) 2:815-22 (2010). WB . PubMed: 21076177
  • Song BS  et al. Nucleologenesis and embryonic genome activation are defective in interspecies cloned embryos between bovine ooplasm and rhesus monkey somatic cells. BMC Dev Biol 9:44 (2009). ICC/IF ; Cow . PubMed: 19635167
  • Hadian K  et al. Identification of a heterogeneous nuclear ribonucleoprotein-recognition region in the HIV Rev protein. J Biol Chem 284:33384-91 (2009). WB ; Human . PubMed: 19808671
  • Rees-Unwin KS  et al. Ribosome-associated nucleophosmin 1: increased expression and shuttling activity distinguishes prognostic subtypes in chronic lymphocytic leukaemia. Br J Haematol : (2009). IP ; Human . PubMed: 19961478
  • Gutiérrez L  et al. Ablation of Gata1 in adult mice results in aplastic crisis, revealing its essential role in steady-state and stress erythropoiesis. Blood 111:4375-85 (2008). PubMed: 18258797
  • Alazami AM  et al. Mutations in C2orf37, encoding a nucleolar protein, cause hypogonadism, alopecia, diabetes mellitus, mental retardation, and extrapyramidal syndrome. Am J Hum Genet 83:684-91 (2008). ICC/IF ; Human . PubMed: 19026396
  • Palaniswamy V  et al. Nucleophosmin is selectively deposited on mRNA during polyadenylation. Nat Struct Mol Biol : (2006). PubMed: 16604083
  • Kind J & van Steensel B Stochastic genome-nuclear lamina interactions: modulating roles of Lamin A and BAF. Nucleus 5:124-30 (0). IF . PubMed: 24717229

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