Product nameAnti-Nucleoporin p62/NUP62 antibody [RL31]
See all Nucleoporin p62/NUP62 primary antibodies
DescriptionArmenian hamster monoclonal [RL31] to Nucleoporin p62/NUP62
Host speciesArmenian hamster
Detects the Nucleoporin p62/NUP62 O-linked glycoprotein in the p62 complex from rat tissues.
Tested applicationsSuitable for: ICC/IF, IP, IHC-Fr, WBmore details
Species reactivityReacts with: Rat, Human, Non human primates, Amphibian
Other Immunogen Type corresponding to Nucleoporin p62/NUP62. Equivalent to O-linked glycoprotein-enriched fraction from rat liver nuclear envelope
- Rat liver nuclear envelope fractions.
This product was previously labelled as Nucleoporin p62
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.05% Sodium azide
Concentration information loading...
Our Abpromise guarantee covers the use of ab2736 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
This antibody stains both the nucleoplasmic and cytoplasmic surfaces of rat's liver Nup62.
|IP||Use at an assay dependent concentration.|
|IHC-Fr||Use at an assay dependent concentration.|
|WB||1/200. Detects a band of approximately 62 kDa (predicted molecular weight: 62 kDa).
This antibody detects a single 62 kDa band in rat liver nuclear envelope fractions.
RelevanceThe nuclear pore complex is a structure that extends across the nuclear envelope and regulates the flow of macromolecules between the cytoplasm and the nucleus. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. Nup 62 is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. There are multiple transcript variants of this gene, however, they encode a single protein isoform. This protein undergoes post-translational modifications. It contains about 10 N-acetylglucosamine side chain sites.
Cellular localizationNucleus; nuclear pore complex. Cytoplasm; cytoskeleton; spindle pole. Note: Central region of the nuclear pore, within the transporter. During mitotic cell division, it associates with the poles of the mitotic spindle.
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This product has been referenced in:
- Jain P et al. Identification of human T cell leukemia virus type 1 tax amino acid signals and cellular factors involved in secretion of the viral oncoprotein. J Biol Chem 282:34581-93 (2007). Read more (PubMed: 17897946) »
- Guan T et al. Structural analysis of the p62 complex, an assembly of O-linked glycoproteins that localizes near the central gated channel of the nuclear pore complex. Mol Biol Cell 6:1591-603 (1995). Read more (PubMed: 8589458) »