Anti-NuMA antibody [A73-B/D12] (ab5675)
Key features and details
- Mouse monoclonal [A73-B/D12] to NuMA
- Reacts with: Human
- Isotype: IgM
Overview
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Product name
Anti-NuMA antibody [A73-B/D12]
See all NuMA primary antibodies -
Description
Mouse monoclonal [A73-B/D12] to NuMA -
Host species
Mouse -
Specificity
Reacts with an intracellular 228 kD protein found in the nucleus during interphase. -
Species reactivity
Reacts with: Human -
Immunogen
Live Ls 174T cells (human colon carcinoma).
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Positive control
- Tonsil, Thymus, Spleen.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.
One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.
Learn more here.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C. Do Not Freeze. -
Storage buffer
pH: 7.40
Preservative: 0.1% Sodium azide
Constituent: PBS -
Concentration information loading...
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Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
A73-B/D12 -
Isotype
IgM -
Research areas
Associated products
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Alternative Versions
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Target
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Function
May be a structural component of the nucleus. -
Cellular localization
Nucleus. Chromosome. Dissociates from condensing chromosomes during early prophase, before the complete disintegration of the nuclear lamina. As mitosis progresses it reassociates with telophase chromosomes very early during nuclear reformation, before substantial accumulation of lamins on chromosomal surfaces is evident. - Information by UniProt
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Database links
- Entrez Gene: 4926 Human
- Omim: 164009 Human
- SwissProt: Q14980 Human
- Unigene: 325978 Human
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Alternative names
- Centrophilin stabilizes mitotic spindle in mitotic cells antibody
- NMP 22 antibody
- Nuclear matrix protein 22 antibody
see all
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (7)
ab5675 has been referenced in 7 publications.
- Beckmann D et al. Hippocampal Synaptic Plasticity, Spatial Memory, and Neurotransmitter Receptor Expression Are Profoundly Altered by Gradual Loss of Hearing Ability. Cereb Cortex 30:4581-4596 (2020). PubMed: 32202614
- Abd-Elrahman KS et al. Autophagy is increased following either pharmacological or genetic silencing of mGluR5 signaling in Alzheimer's disease mouse models. Mol Brain 11:19 (2018). PubMed: 29631635
- Burch A et al. A novel synaptic junction preparation for the identification and characterization of cleft proteins. PLoS One 12:e0174895 (2017). PubMed: 28362857
- Goniotaki D et al. Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity. PLoS Pathog 13:e1006733 (2017). PubMed: 29176838
- Han K et al. SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties. Nature 503:72-7 (2013). PubMed: 24153177
- Shi JG et al. Tissue engineering of ureteral grafts by seeding urothelial differentiated hADSCs onto biodegradable ureteral scaffolds. J Biomed Mater Res A 100:2612-22 (2012). ICC/IF . PubMed: 22615210
- Kwong J et al. An antagonist of the chemokine receptor CXCR4 induces mitotic catastrophe in ovarian cancer cells. Mol Cancer Ther 8:1893-905 (2009). PubMed: 19567818