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    nurr1-antibody-ab176184.pdf

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Neuroscience Neurology process Neurodegenerative disease Parkinson's disease Other
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Anti-Nurr1 antibody (ab176184)

  • Datasheet
  • SDS
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nurr1 antibody (ab176184)
  • Western blot - Anti-Nurr1 antibody (ab176184)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nurr1 antibody (ab176184)

Key features and details

  • Rabbit polyclonal to Nurr1
  • Suitable for: WB, IHC-P
  • Reacts with: Mouse
  • Isotype: IgG

You may also be interested in

Secondary
Product image
Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

View more associated products

Overview

  • Product name

    Anti-Nurr1 antibody
    See all Nurr1 primary antibodies
  • Description

    Rabbit polyclonal to Nurr1
  • Host species

    Rabbit
  • Tested Applications & Species

    Application Species
    IHC-P
    Mouse
    WB
    Mouse
    See all applications and species data
  • Immunogen

    Synthetic peptide within Human Nurr1 aa 566-591. The exact sequence is proprietary. The selected peptide was post-synthetically modified to achieve highest antigenicity before coupling to carrier protein using hetero bifunctional cross linker.
    Sequence:

    CTQGLQRIFYLKLEDLVPPPAIIDKL


    Database link: P43354
    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.

    One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.

    Learn more here.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.02% Sodium azide
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Neuroscience
    • Neurology process
    • Neurodegenerative disease
    • Parkinson's disease
    • Other
    • Neuroscience
    • Neurology process
    • Neural Signal Transduction
    • Immunology
    • Immune System Diseases
    • Autoimmune
    • Neuroscience
    • Neurology process
    • Neurogenesis
    • Epigenetics and Nuclear Signaling
    • Transcription
    • Other factors
    • Cancer
    • Cancer Metabolism
    • Response to hypoxia
    • Metabolism
    • Pathways and Processes
    • Metabolism processes
    • Hypoxia

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Recombinant Protein

    • Recombinant Human Nurr1 protein (His tag) (ab241530)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab176184 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Guaranteed

Tested applications are guaranteed to work and covered by our Abpromise guarantee.

Predicted

Predicted to work for this combination of applications and species but not guaranteed.

Incompatible

Does not work for this combination of applications and species.

Application Species
IHC-P
Mouse
WB
Mouse
Application Abreviews Notes
WB
1/500. Detects a band of approximately 75 kDa (predicted molecular weight: 67 kDa).
IHC-P
1/50 - 1/100.
Notes
WB
1/500. Detects a band of approximately 75 kDa (predicted molecular weight: 67 kDa).
IHC-P
1/50 - 1/100.

Target

  • Function

    Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons.
  • Tissue specificity

    Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue.
  • Sequence similarities

    Belongs to the nuclear hormone receptor family. NR4 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • Developmental stage

    Rapidly and only very transiently expressed after cell activation, during the G0-G1 transition of the cell cycle.
  • Cellular localization

    Nucleus.
  • Target information above from: UniProt accession P43354 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 18227 Mouse
    • SwissProt: Q06219 Mouse
    • Unigene: 3507 Mouse
    • Alternative names

      • HZF 3 antibody
      • HZF3 antibody
      • Immediate-early response protein NOT antibody
      • Intermediate early receptor protein antibody
      • NGFI B/nur77 beta type transcription factor homolog antibody
      • NOT antibody
      • Nr4a2 antibody
      • NR4A2_HUMAN antibody
      • nuclear receptor of T cells antibody
      • nuclear receptor related 1 antibody
      • Nuclear receptor subfamily 4 group A member 2 antibody
      • Nur related protein 1 homolog antibody
      • nur related protein-1, human homolog of antibody
      • Nurr 1 antibody
      • Orphan nuclear receptor NR4A2 antibody
      • Orphan nuclear receptor NURR1 antibody
      • RNR 1 antibody
      • RNR1 antibody
      • T cell nuclear receptor NOT antibody
      • T-cell nuclear receptor NOT antibody
      • TINUR antibody
      • Transcriptionally inducible nuclear receptor antibody
      • Transcriptionally inducible nuclear receptor related antibody
      • Transcriptionally inducible nuclear receptor related 1 antibody
      • Transcriptionally-inducible nuclear receptor antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nurr1 antibody (ab176184)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nurr1 antibody (ab176184)

      Formalin-fixed, paraffin-embedded mouse kidney tissue stained for Nurr1 using ab176184 at 1:50 dilution (IHC Blocking Buffer) in immunohistochemical analysis. Hematoxylin QS (blue) was used to cunterstain.

    • Western blot - Anti-Nurr1 antibody (ab176184)
      Western blot - Anti-Nurr1 antibody (ab176184)
      All lanes : Anti-Nurr1 antibody (ab176184) at 1/500 dilution

      Lane 1 : Mouse skeletal muscle tissue lysate
      Lane 2 : Mouse heart tissue lysate
      Lane 3 : Mouse liver tissue lysate
      Lane 4 : Mouse kidney tissue lysate
      Lane 5 : Mouse lung tissue lysate
      Lane 6 : Mouse large intestine tissue lysate
      Lane 7 : Mouse small intestine tissue lysate
      Lane 8 : Mouse spleen tissue lysate
      Lane 9 : Mouse ovary tissue lysate
      Lane 10 : Mouse bladder tissue lysate
      Lane 11 : Mouse cerebellum tissue lysate
      Lane 12 : Mouse spinal cord tissue lysate
      Lane 13 : Mouse brain tissue lysate

      Predicted band size: 67 kDa

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nurr1 antibody (ab176184)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nurr1 antibody (ab176184)

      Formalin-fixed, paraffin-embedded mouse kidney tissue stained for Nurr1 using ab176184 at 1:50 dilution (IHC Blocking Buffer) in immunohistochemical analysis. Hematoxylin QS (blue) was used to cunterstain.

    Protocols

    • Western blot protocols

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (0)

    Publishing research using ab176184? Please let us know so that we can cite the reference in this datasheet.

    ab176184 has not yet been referenced specifically in any publications.

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