Overview

  • Product name

    NVP-BSK805, ATP-competitive JAK2 inhibitor
  • Description

    Potent, selective, ATP-competitive JAK2 inhibitor.
  • Alternative names

    • 8-(3,5-difluoro-4-(morpholinomethyl)phenyl)-2-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)quinoxaline
    • BSK 805
    • BSK805
    • HY-14722
  • Biological description

    Potent, selective, ATP-competitive JAK2 inhibitor (IC50 = 0.5 nM). Within the JAK family displays more than 20-fold selectivity towards JAK2 in vitro.

  • Purity

    > 95%
  • CAS Number

    1092499-93-8
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Kamigaki M  et al. The Toll-like receptor 4-activated neuroprotective microglia subpopulation survives via granulocyte macrophage colony-stimulating factor and JAK2/STAT5 signaling. Neurochem Int 93:82-94 (2016). Read more (PubMed: 26802935) »
  • Ringel F  et al. Effects of Jak2 type 1 inhibitors NVP-BSK805 and NVP-BVB808 on Jak2 mutation-positive and Bcr-Abl-positive cell lines. Acta Haematol 132:75-86 (2014). Read more (PubMed: 24504330) »
  • Baffert F  et al. Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805. Mol Cancer Ther 9:1945-55 (2010). Read more (PubMed: 20587663) »

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