Overview

  • Product name

    NVP DPP 728, DPP-IV inhibitor
  • Description

    Potent, selective, reversible DPP-IV inhibitor
  • Biological description

    Potent, selective, reversible dipeptidyl peptidase-IV (DPP-IV) inhibitor (Ki = 11 nM). Antidiabetic agent in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    247016-69-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    6-[2-[[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]amino]ethylamino] pyridine-3-carbonitrile dihydrochloride
  • Molecular weight

    371.27
  • Molecular formula

    C15H18N6O.2HCl
  • PubChem identifier

    9799555
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CC(N(C1)C(=O)CNCCNC2=NC=C(C=C2)C#N)C#N.Cl.Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Davis JA  et al. Nature of action of Sitagliptin, the dipeptidyl peptidase-IV inhibitor in diabetic animals. Indian J Pharmacol 42:229-33 (2010). Read more (PubMed: 20927248) »
  • Mitani H  et al. Dipeptidyl peptidase IV inhibitor NVP-DPP728 ameliorates early insulin response and glucose tolerance in aged rats but not in aged Fischer 344 rats lacking its enzyme activity. Jpn J Pharmacol 88:451-8 (2002). Read more (PubMed: 12046989) »
  • Hughes TE  et al. NVP-DPP728 (1-[[[2-[(5-cyanopyridin-2-yl)amino]ethyl]amino]acetyl]-2-cyano-(S)- pyrrolidine), a slow-binding inhibitor of dipeptidyl peptidase IV. Biochemistry 38:11597-603 (1999). Read more (PubMed: 10512614) »

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