Overview

  • Product name

    NVP-TAE684, ALK inhibitor
  • Description

    Highly potent, selective ALK inhibitor
  • Biological description

    Highly potent, selective ALK inhibitor in vitro (IC50 = 2 nM). Suppresses lymphomagenesis in vivo. Down-regulates CD30 expression. Antitumor agent. Potent LRRK2 kinase inhibitor (IC50 = 7.8 nM).
  • Purity

    > 98%
  • CAS Number

    761439-42-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-Chloro-2-N-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl] phenyl]-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine
  • Molecular weight

    614.20
  • Molecular formula

    C30H40ClN7O3S
  • PubChem identifier

    16038120
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCC(CC4)N5CCN (CC5)C)OC
  • Source

    Synthetic

  • Research areas

References

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