Overview

  • Product name

    NVS-PAK1-1, PAK1 inhibitor
  • Description

    Potent allosteric inhibitor of PAK1
  • Biological description

    NVS-PAK1-1 is a potent allosteric inhibitor of p21-activated kinase PAK1. It has an IC50 value of 5 nM for dephoshorylated PAK1 and 6 nM for phosphorylated PAK1 in an in vitro assay. It is more than 50-fold more active against PAK1 than against PAK2. NVS-PAK1-1 is highly selective in a panel of 442 kinases. NVS-PAK1-1 potently inhibits PAK1 autophosphorylation in cell-based assays.

  • Purity

    > 98%
  • CAS Number

    1783816-74-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N-isopropylpyrrolidine-1-carboxamide

  • Molecular weight

    479.93
  • Molecular formula

    C23H25ClF3N5O
  • Storage instructions

    Shipped at room temperature. Store at -20°C.
  • Solubility overview

    Soluble in ethanol to 100 mM and in DMSO to 100 mM

  • SMILES

    O=C(NC(C)C)N4CC[C@H](NC1=Nc3cc(F)ccc3N(CC(F)F)c2ccc(Cl)cc12)C4
  • Source

    Synthetic

References

ab146939 has not yet been referenced specifically in any publications.

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