Product nameNystatin (aqueous), polyene macrolide antifungal
DescriptionPolyene macrolide antifungal; channel-forming ionophore.
Polyene macrolide antifungal, acts by binding to ergosterols in fungal cell membranes, increasing permeability of the membrane, and creating nystatin/ergosterol based ion channels.
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSupplied in water (5 mg/ml)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Kim S & Choi IH Phagocytosis and endocytosis of silver nanoparticles induce interleukin-8 production in human macrophages. Yonsei Med J 53:654-7 (2012). Read more (PubMed: 22477013) »
- Sun B et al. Distinct mechanisms for OxLDL uptake and cellular trafficking by class B scavenger receptors CD36 and SR-BI. J Lipid Res 48:2560-70 (2007). Read more (PubMed: 17876058) »
- Koseki M et al. Increased lipid rafts and accelerated lipopolysaccharide-induced tumor necrosis factor-alpha secretion in Abca1-deficient macrophages. J Lipid Res 48:299-306 (2007). Read more (PubMed: 17079792) »
- Fjaervik E & Zotchev SB Biosynthesis of the polyene macrolide antibiotic nystatin in Streptomyces noursei. Appl Microbiol Biotechnol 67:436-43 (2005). Read more (PubMed: 15700127) »
- Hunt GR et al. Phosphatidic acid regulates the activity of the channel-forming ionophores alamethicin, melittin, and nystatin: a 1H-NMR study using phospholipid membranes. Biosci Rep 4:403-13 (1984). Read more (PubMed: 6329354) »