Nystatin, channel-forming ionophore. (ab141118)

Overview

  • Product name

    Nystatin, channel-forming ionophore.
  • Description

    Macrolide antibiotic agent. Channel-forming ionophore.
  • Biological description

    Macrolide antibiotic agent. Channel-forming ionophore. Binds to cell membrane sterols. Induces K+-efflux. Shows antifungal effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    1400-61-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (4E,6E,8E,10E,14E,16E,18S,19R,20R,21S,35S)-3-[(2S,3S,4S,5S,6R)-4-Amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-19,25,27,29,32,33,35,37-octahydroxy-18,20,21-trimethyl-23-oxo-22,39-dioxabicyclo[33.3.1]nonatriaconta-4,6,8,10,14,16-hexaene-38-carboxylic acid
  • Molecular weight

    926.09
  • Molecular formula

    C47H75NO17
  • PubChem identifier

    6433272
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C[C@H]1/C=C/C=C/CC/C=C/C=C/C=C/C=C/C(CC2C(C(C[C@](O2)(CC(C(CCC(CC(CC(CC(=O)O[C@H]([C@@H]([C@@H]1O)C)C)O)O)O)O)O)O)O)C(=O)O)O[C@@H]3[C@H]([C@H]([C@@H]([C@H](O3)C)O)N)O
  • Source

    Candida sp.

References

This product has been referenced in:

  • Yamasaki M  et al. Effects and mechanisms of action of polyene macrolide antibiotic nystatin on Babesia gibsoni in vitro. J Parasitol 97:1190-2 (2011). Read more (PubMed: 21756054) »
  • Li SY  et al. Effect of genistein on voltage-gated potassium channels in guinea pig proximal colon smooth muscle cells. World J Gastroenterol 12:420-5 (2006). Read more (PubMed: 16489642) »
  • Caballero R  et al. Interaction of angiotensin II with the angiotensin type 2 receptor inhibits the cardiac transient outward potassium current. Cardiovasc Res 62:86-95 (2004). Read more (PubMed: 15023555) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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