Overview

  • Product name

    O-1602, GPR55 agonist
  • Description

    Potent, selective GPR55 agonist
  • Biological description

    Analog of cannabidiol that is a potent agonist at the GPR55 cannabinoid receptor (EC50 values are 13, >30000 and >30000 nM for GPR55, CB1 and CB2 receptors, respectively). Inhibits mouse osteoclast formation in vitro, stimulates osteoclast polarization and resorption, causes activation of Rho and ERK1/2, and inhibits human neutrophil migration.
  • Purity

    > 98%
  • General notes

    Sold under license from Virginia Commonwealth University.
  • CAS Number

    317321-41-8
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Whyte LS  et al. The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo. Proc Natl Acad Sci U S A 106:16511-6 (2009). Read more (PubMed: 19805329) »
  • McHugh D  et al. Inhibition of human neutrophil chemotaxis by endogenous cannabinoids and phytocannabinoids: evidence for a site distinct from CB1 and CB2. Mol Pharmacol 73:441-50 (2008). Read more (PubMed: 17965195) »
  • Ryberg E  et al. The orphan receptor GPR55 is a novel cannabinoid receptor. Br J Pharmacol 152:1092-101 (2007). Read more (PubMed: 17876302) »
See 1 Publication for this product

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