• Product name

    Anti-OATP1B1 antibody [MDQ]
    See all OATP1B1 primary antibodies
  • Description

    Mouse monoclonal [MDQ] to OATP1B1
  • Host species

  • Specificity

    Ab15442 will also cross react with OATP8.
  • Tested applications

    Suitable for: WB, IHC-Fr, ICC/IF, IPmore details
  • Species reactivity

    Reacts with: Human
    Does not react with: Mouse, Rat, Dog
  • Immunogen

    Synthetic peptide corresponding to Human OATP1B1 aa 1-23.


  • Positive control

    • Human liver tissue slides.
  • General notes

     This product was previously labelled as OATP2




Our Abpromise guarantee covers the use of ab15442 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration.
IHC-Fr 1/20.
ICC/IF 1/20.
IP Use at an assay dependent concentration.


  • Function

    Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. May play an important role in the clearance of bile acids and organic anions from the liver.
  • Tissue specificity

    Highly expressed in liver. Not detected in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte.
  • Sequence similarities

    Belongs to the organo anion transporter (TC 2.A.60) family.
    Contains 1 Kazal-like domain.
  • Cellular localization

    Basolateral cell membrane. Detected in basolateral membranes of hepatocytes.
  • Information by UniProt
  • Database links

  • Alternative names

    • Liver-specific organic anion transporter 1 antibody
    • LST-1 antibody
    • LST1 antibody
    • OATP-2 antibody
    • OATP-C antibody
    • OATP1B1 antibody
    • OATPC antibody
    • SLC21A6 antibody
    • SLCO1B1 antibody
    • SO1B1_HUMAN antibody
    • Sodium-independent organic anion-transporting polypeptide 2 antibody
    • Solute carrier family 21 member 6 antibody
    • Solute carrier organic anion transporter family member 1B1 antibody
    see all


  • Immunocytochemistry/Immunofluorescence analysis of HepG2 cells labeling OATP1B1 (green) with ab15542 at 1/20. F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue). Cells were fixed with formaldehyde and incubated with the primary antibody overnight at 4°C. A DyLight 488-conjugated secondary antibody was used. 60X magnification. Right - negative control.


This product has been referenced in:

  • Imada S  et al. Central bisectionectomy for hepatocellular carcinoma in a patient with indocyanine green excretory defect associated with reduced expression of the liver transporter. Surg Case Rep 2:89 (2016). Read more (PubMed: 27589984) »
  • Peng JF  et al. Role of miR-511 in the Regulation of OATP1B1 Expression by Free Fatty Acid. Biomol Ther (Seoul) 23:400-6 (2015). WB . Read more (PubMed: 26336578) »
See all 3 Publications for this product

Customer reviews and Q&As

1-4 of 4 Q&A


Any products that require an MSDS form will have a link on the product's online datasheet to the data. It will be a PDF document link labeled 'SDS'. Please see attached image for example of what to look for on the datasheet. If no 'SDS' link is available than the product does not contain any components that require an SDS.

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Thank you for your enquiry. I am sorry to hear that you have been having difficulties with this antibody. I have read through your technical questionaire and I have a few comments. OATP2 antibody [MDQ] (ab15442) has been tested for its applications of immunofluorescence, immunohistochemistry (Frozen sections) and immunoprecipitation. To our knowledge we are not aware of how this antibody behaves in western blotting. Therefore unfortunately we cannot guarantee it for this purpose. I am sorry to hear that you have observed differences between the batches of antibody that you have used. This is a monoclonal antibody and I would not expect different antibody preparations to have significant variation in their quality. However, occasional batch to batch variation does exist. Therefore given this I would like to recommend that you perform the optimisation to your protocol; Firstly I would like to suggest that you verify the integrity of your sample and preparation by performing a loading control immunolabelling using an antibody that targets a housekeeping protein such as GAPDH or alpha tubulin. Following on I would like to suggest that you significantly reduce the dilution of the antibody to ~1:20 in view of the antibody dilutions recommended for immunofluorescence and perform an overnight incubation at 4oC using BSA as a blocking agent. This serves to improve the sensitivity of the antibody.

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Thank you for your enquiry. Both antibodies were tested in IP using human liver samples (~20-50 ug) and about 1 ug/ml of antibody used. For IF, human liver and transfected HEK293 whole cell lysates were used. Ab15442 was used at a dilution of 1:20. The fixative was 4% PFA for ~10-15 minutes. Ab15441 was used at 1:100 in IF. If you have any additional questions, please contact us again.

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Thank you for bringing this to our attention. The immunogen sequence is from OATP2, however this product will also recognise OATP8. The data sheet has now been updated to reflect this. Please let me know if you spot any further problems. I apologize for any inconvenience that this may have caused.

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