Overview

  • Product name

  • Description

    Rabbit polyclonal to OBFC2A
  • Host species

    Rabbit
  • Tested applications

    Suitable for: ICC/IFmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Pig, Rhesus monkey
  • Immunogen

    Recombinant fragment within Human OBFC2A (internal sequence). The exact sequence is proprietary.
    Database link: Q96AH0

  • Positive control

    • ICC/IF: HL-60 cells.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: PBS, 20% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab229166 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF 1/100 - 1/1000.

Target

  • Function

    Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.
  • Sequence similarities

    Belongs to the SOSS-B family. SOSS-B2 subfamily.
    Contains 1 OB DNA-binding domain.
  • Cellular localization

    Nucleus. Localizes to nuclear foci following DNA damage.
  • Information by UniProt
  • Database links

  • Alternative names

    • FLJ13624 antibody
    • FLJ22833 antibody
    • hSSB2 antibody
    • MGC111163 antibody
    • Nabp1 antibody
    • Nucleic acid-binding protein 1 antibody
    • OBFC2A antibody
    • Oligonucleotide/oligosaccharide binding fold containing 2A antibody
    • Oligonucleotide/oligosaccharide binding fold containing protein 2A antibody
    • Oligonucleotide/oligosaccharide-binding fold-containing protein 2A antibody
    • Sensor of single strand DNA complex subunit B2 antibody
    • Sensor of single-strand DNA complex subunit B2 antibody
    • Sensor of ssDNA subunit B2 antibody
    • Single stranded DNA binding protein 2 antibody
    • Single-stranded DNA-binding protein 2 antibody
    • SOSB2_HUMAN antibody
    • SOSS B2 antibody
    • SOSS complex subunit B2 antibody
    • SOSS-B2 antibody
    • SSB2 antibody
    see all

Images

  • HL-60 (human promyelocytic leukemia cell line) cells stained for OBFC2A (green) using ab229166 (1/500 dilution) in ICC/IF. Cells were fixed in 4% paraformaldehyde at RT for 15 minutes.

    Nuclear counterstain: Hoechst 33342 (blue).

References

ab229166 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab229166.
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