Product nameAnti-OBFC2A antibody
See all OBFC2A primary antibodies
DescriptionRabbit polyclonal to OBFC2A
Tested applicationsSuitable for: ICC/IFmore details
Species reactivityReacts with: Human
Predicted to work with: Pig, Rhesus monkey
Recombinant fragment within Human OBFC2A (internal sequence). The exact sequence is proprietary.
Database link: Q96AH0
- ICC/IF: HL-60 cells.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: PBS, 20% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab229166 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ICC/IF||1/100 - 1/1000.|
FunctionComponent of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.
Sequence similaritiesBelongs to the SOSS-B family. SOSS-B2 subfamily.
Contains 1 OB DNA-binding domain.
Cellular localizationNucleus. Localizes to nuclear foci following DNA damage.
- Information by UniProt
- FLJ13624 antibody
- FLJ22833 antibody
- hSSB2 antibody
ab229166 has not yet been referenced specifically in any publications.