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Signal Transduction Protein Trafficking Vesicle Transport Regulation
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OcTMAB™, dynamin I and dynamin II inhibitor (ab120467)

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Functional Studies - OcTMAB™, dynamin I and dynamin II inhibitor (ab120467)

    Key features and details

    • Cell-permeable dynamin I and dynamin II inhibitor
    • CAS Number: 1120-02-1
    • Soluble in DMSO to 25 mM (with warming)
    • Form / State: Solid
    • Source: Synthetic

    Overview

    • Product name

      OcTMAB™, dynamin I and dynamin II inhibitor
    • Description

      Cell-permeable dynamin I and dynamin II inhibitor
    • Biological description

      Cell-permeable dynamin I and dynamin II inhibitor (IC50 values are 1.9 and 4.4 μM for inhibition of dynamin I and II GTPase, respectively). Targets the pleckstrin homology (PH) (lipid binding) domain. Competitive with phospholipid and non-competitive with GTP. Inhibits receptor-mediated endocytosis (IC50 = 6.7 μM). Inhibits cancer cell growth.

    • General notes

      Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd. OcTMAB™ is a trademark of Children's Medical Research Institute and Newcastle Innovation Ltd.
    • CAS Number

      1120-02-1
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      Octadecyltrimethylammonium bromide
    • Molecular weight

      392.51
    • Molecular formula

      C21H46BrN
    • PubChem identifier

      70708
    • Storage instructions

      Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in DMSO to 25 mM (with warming)
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      [Br-].C[N+](C)(C)CCCCCCCCCCCCCCCCCC
    • Source

      Synthetic

    • Research areas

      • Signal Transduction
      • Protein Trafficking
      • Vesicle Transport
      • Regulation
      • Neuroscience
      • Cell Type Marker
      • Neuron marker
      • Synapse marker
      • Biochemicals
      • Chemical Type
      • Biochemicals
      • Biochemicals
      • Pharmacology
      • Enzymes
      • ATPase & GTPase
      • Inhibitors
      • Biochemicals
      • Pharmacology
      • Signaling
      • Endocytosis & exocytosis
      • Dynamin
      • Biochemicals
      • Research Area
      • Heart disease
      • Signaling
      • Endocytosis & exocytosis
      • Dynamin
      • Biochemicals
      • Research Area
      • Pain & inflammation
      • Signaling
      • Endocytosis & exocytosis
      • Dynamin
      • Biochemicals
      • Research Area
      • Alzheimer's Disease
      • Signaling
      • Endocytosis & exocytosis
      • Dynamin
      • Biochemicals
      • Research Area
      • Diabetes
      • Signaling
      • Endocytosis & exocytosis
      • Dynamin
      • Biochemicals
      • Research Area
      • Hypertension
      • Signaling
      • Endocytosis & exocytosis
      • Dynamin
      • Biochemicals
      • Research Area
      • Obesity
      • Signaling
      • Endocytosis & exocytosis
      • Dynamin
      • Biochemicals
      • Research Area
      • Respiratory disease
      • Signaling
      • Endocytosis & exocytosis
      • Dynamin
      • Biochemicals
      • Research Area
      • Stroke
      • Signaling
      • Endocytosis & exocytosis
      • Dynamin

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab120467 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    Functional Studies
    Use at an assay dependent concentration.
    Notes
    Functional Studies
    Use at an assay dependent concentration.

    Images

    • Functional Studies - OcTMAB™, dynamin I and dynamin II inhibitor (ab120467)
      Functional Studies - OcTMAB™, dynamin I and dynamin II inhibitor (ab120467)
      ab66705 staining PAI1 in HeLa cells treated with OcTMAB™ (ab120467), by ICC/IF. Increase in PAI1 expression correlates with increased concentration of OcTMAB™, as described in literature.
      The cells were incubated at 37°C for 24h in media containing different concentrations of ab120467 (OcTMAB™) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab66705 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download
    • COA

    References (0)

    Publishing research using ab120467? Please let us know so that we can cite the reference in this datasheet.

    ab120467 has not yet been referenced specifically in any publications.

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