Overview

  • Product name

    ODQ, NO-sensitive guanylyl cyclase inhibitor 
  • Description

    Selective, potent inhibitor of NO-sensitive guanylyl cyclase
  • Biological description

    Selective, potent inhibitor of nitric oxide-sensitive guanylyl cyclase.
  • Purity

    > 99%
  • CAS Number

    41443-28-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
  • Molecular weight

    187.16
  • Molecular formula

    C9H5N3O2
  • PubChem identifier

    1456
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    O=C2ON=C3C=Nc1ccccc1N23
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Homer KL  et al. Inhibition by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) of responses to nitric oxide-donors in rat pulmonary artery: influence of the mechanism of nitric oxide generation. J Pharm Pharmacol 51:135-9 (1999). Read more (PubMed: 10217311) »
  • Schrammel A  et al. Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase. Mol Pharmacol 50:1-5 (1996). Read more (PubMed: 8700100) »
  • Garthwaite J  et al. Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one. Mol Pharmacol 48:184-8 (1995). Read more (PubMed: 7544433) »
See all 4 Publications for this product

Customer reviews and Q&As

1-3 of 3 Abreviews or Q&A

Answer

Thank you for confirming these details and for your cooperation. The details provided enable us to closely monitor the quality of our products.

I am sorry this product did not perform as stated on the datasheet and for the inconvenience this has caused. As requested, I have issued a free of charge replacement with the order number 1114328.

To check the status of the order please contact our Customer Service team and reference this number.

Please note that this free of charge replacement vial is also covered by our Abpromise guarantee. Should you still be experiencing difficulties, or if you have any further questions, please do not hesitate to let us know.

I wish you the best of luck with your research.

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Answer

Thank you for contacting us.

Our chemists have tested the DMSO solubility of the compound. After 25 min at ambient temperature the solution remained colourless.We are presumingsince the issue was with the particular vial you have received andthere isno other way to determine fromwhere the colour came so we are happyto send you a replacement vial.

Could you please provide the purchase order number?

I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

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