Overview

  • Product name

  • Description

    Goat polyclonal to Ogg1
  • Host species

    Goat
  • Specificity

    This antibody is expected to recognise isoform 1a only.
  • Tested applications

    Suitable for: WB, ELISAmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide:

    DLRQSRHAQEPPAK

    by a Cysteine residue linker, corresponding to C terminal amino acids 322-335 of Human Ogg1

  • Positive control

    • Human Brain (Cerebellum) lysate

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • Storage buffer

    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Purification notes

    ab63942 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab63942 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notes
    ELISA: Use at an assay dependent dilution. Antibody detection limit dilution for peptide ELISA: 1/32000
    WB: Use at a concentration of 0.2 - 0.6 µg/ml. Detects a band of approximately 39 kDa (predicted molecular weight: 39 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.
    • Tissue specificity

      Ubiquitous.
    • Involvement in disease

      Defects in OGG1 may be a cause of renal cell carcinoma (RCC) [MIM:144700]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.
    • Sequence similarities

      Belongs to the type-1 OGG1 family.
    • Cellular localization

      Mitochondrion; Nucleus and Nucleus > nucleoplasm. Nucleus speckle. Nucleus matrix. Together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells.
    • Information by UniProt
    • Database links

    • Alternative names

      • 8 hydroxyguanine DNA glycosylase antibody
      • 8 oxoguanine DNA glycosylase 1 antibody
      • 8 oxoguanine DNA glycosylase antibody
      • AP lyase antibody
      • DNA (apurinic or apyrimidinic site) lyase antibody
      • DNA apurinic or apyrimidinic site lyase antibody
      • DNA lyase antibody
      • DNA-(apurinic or apyrimidinic site) lyase antibody
      • HMMH antibody
      • HOGG 1 antibody
      • HOGG1 antibody
      • MMH antibody
      • MUTM antibody
      • N glycosylase antibody
      • Ogg 1 antibody
      • Ogg1 antibody
      • OGG1_HUMAN antibody
      • OGH 1 antibody
      • OGH1 antibody
      see all

    Images

    • Anti-Ogg1 antibody (ab63942) at 0.2 µg/ml + Human Brain (Cerebellum) lysate at 35 µg

      Predicted band size: 39 kDa
      Observed band size: 39 kDa

    References

    ab63942 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab63942.
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