Overview

  • Product name

    Anti-Ogg1 antibody [EPR4664(2)] - BSA and Azide free
    See all Ogg1 primary antibodies
  • Description

    Rabbit monoclonal [EPR4664(2)] to Ogg1 - BSA and Azide free
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC, WBmore details
    Unsuitable for: ICC/IF
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human Ogg1 aa 300 to the C-terminus (C terminal). The exact sequence is proprietary.

  • General notes

    ab239996 is the carrier-free version of ab124741 This format is designed for use in antibody labeling, including fluorochromes, metal isotopes, oligonucleotides, enzymes.

     

    Our carrier-free formats are supplied in a buffer free of BSA, sodium azide and glycerol for higher conjugation efficiency.

    Use our conjugation kits  for antibody conjugates that are ready-to-use in as little as 20 minutes with <1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

    Ab239996 is compatible with the Maxpar® Antibody Labeling Kit from Fluidigm.

    Maxpar® is a trademark of Fluidigm Canada Inc.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab239996 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC Use at an assay dependent concentration. PubMed: 25267977
WB Use at an assay dependent concentration. Detects a band of approximately 39 kDa (predicted molecular weight: 39 kDa).
  • Application notes
    Is unsuitable for ICC/IF.
  • Target

    • Function

      DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.
    • Tissue specificity

      Ubiquitous.
    • Involvement in disease

      Defects in OGG1 may be a cause of renal cell carcinoma (RCC) [MIM:144700]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.
    • Sequence similarities

      Belongs to the type-1 OGG1 family.
    • Cellular localization

      Mitochondrion; Nucleus and Nucleus > nucleoplasm. Nucleus speckle. Nucleus matrix. Together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells.
    • Information by UniProt
    • Database links

    • Alternative names

      • 8 hydroxyguanine DNA glycosylase antibody
      • 8 oxoguanine DNA glycosylase 1 antibody
      • 8 oxoguanine DNA glycosylase antibody
      • AP lyase antibody
      • DNA (apurinic or apyrimidinic site) lyase antibody
      • DNA apurinic or apyrimidinic site lyase antibody
      • DNA lyase antibody
      • DNA-(apurinic or apyrimidinic site) lyase antibody
      • HMMH antibody
      • HOGG 1 antibody
      • HOGG1 antibody
      • MMH antibody
      • MUTM antibody
      • N glycosylase antibody
      • Ogg 1 antibody
      • Ogg1 antibody
      • OGG1_HUMAN antibody
      • OGH 1 antibody
      • OGH1 antibody
      see all

    Images

    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

      This data was developed using the same antibody clone in a different buffer formulation containing PBS, BSA, glycerol, and sodium azide (ab124741).

    References

    ab239996 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab239996.
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