Okadaic acid, PP1 and PP2A inhibitor (ab120375)
Overview
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Product name
Okadaic acid, PP1 and PP2A inhibitor -
Description
PP1 and PP2A inhibitor -
Biological description
Potent inhibitor of protein phosphatase 1 (IC50 = 3 - 15 nM) and protein phosphatase 2A (IC50 = 0.1-1 nM). Highly selective over PP2B, PP2C and a range of other phosphatases. Tumor promotor. -
CAS Number
78111-17-8 -
Chemical structure
Properties
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Chemical name
9,10-Deepithio-9,10-didehydroacanthifolicin -
Molecular weight
805.01 -
Molecular formula
C44H68O13 -
PubChem identifier
446512 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[C@@H]2CC[C@]1(CCCCO1)O[C@@H]2[C@@H](C)C[C@H](O)[C@H]6O[C@@H]7CC[C@@]3(CC[C@@H](O3)/C=C/[C@@H](C)[C@@H]5CC(C)=C[C@@]4(O[C@@H](CC[C@H]4O)C[C@@](C)(O)C(=O)O)O5)O[C@H]7[C@H](O)C6=C -
Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References
ab120375 has been referenced in 12 publications.
- Jiménez-Cárcamo D et al. Toxins of Okadaic Acid-Group Increase Malignant Properties in Cells of Colon Cancer. Toxins (Basel) 12:N/A (2020). PubMed: 32183214
- Berndsen K et al. PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins. Elife 8:N/A (2019). PubMed: 31663853
- Boban M et al. Human neuroblastoma SH-SY5Y cells treated with okadaic acid express phosphorylated high molecular weight tau-immunoreactive protein species. J Neurosci Methods 319:60-68 (2019). PubMed: 30278184
- Xiao Z et al. SDHB downregulation facilitates the proliferation and invasion of colorectal cancer through AMPK functions excluding those involved in the modulation of aerobic glycolysis. Exp Ther Med 15:864-872 (2018). PubMed: 29399091
- Zhu Y et al. a- and ß-Naphthoflavone synergistically attenuate H2O2-induced neuron SH-SY5Y cell damage. Exp Ther Med 13:1143-1150 (2017). PubMed: 28450955
