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  1. Link

    okadaic-acid-pp1-and-pp2a-inhibitor-ab120375.pdf

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Cell Biology Cell Cycle Kinases/Phosphatases Phosphatases
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Okadaic acid, PP1 and PP2A inhibitor (ab120375)

  • Datasheet
  • SDS
Reviews (1) Submit a question References (14)

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Chemical Structure - Okadaic acid, PP1 and PP2A inhibitor (ab120375)

    Key features and details

    • PP1 and PP2A inhibitor
    • CAS Number: 78111-17-8
    • Soluble in DMSO to 100 mM

    • Form / State: Solid

    Overview

    • Product name

      Okadaic acid, PP1 and PP2A inhibitor
    • Description

      PP1 and PP2A inhibitor
    • Biological description

      Potent inhibitor of protein phosphatase 1 (IC50 = 3 - 15 nM) and protein phosphatase 2A (IC50 = 0.1-1 nM). Highly selective over PP2B, PP2C and a range of other phosphatases. Tumor promotor.
    • CAS Number

      78111-17-8
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      9,10-Deepithio-9,10-didehydroacanthifolicin

    • Molecular weight

      805.01
    • Molecular formula

      C44H68O13
    • PubChem identifier

      446512
    • Storage instructions

      Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in DMSO to 100 mM

    • Handling

      This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Toxic, refer to SDS for further information.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      C[C@@H]2CC[C@]1(CCCCO1)O[C@@H]2[C@@H](C)C[C@H](O)[C@H]6O[C@@H]7CC[C@@]3(CC[C@@H](O3)/C=C/[C@@H](C)[C@@H]5CC(C)=C[C@@]4(O[C@@H](CC[C@H]4O)C[C@@](C)(O)C(=O)O)O5)O[C@H]7[C@H](O)C6=C
    • Research areas

      • Cell Biology
      • Cell Cycle
      • Kinases/Phosphatases
      • Phosphatases
      • Cell Biology
      • Cell Cycle
      • Kinases/Phosphatases
      • Other
      • Neuroscience
      • Neurotransmission
      • Intracellular Signaling
      • Phosphatases
      • Signal Transduction
      • Protein Phosphorylation
      • Tyrosine Phosphatases
      • Signal Transduction
      • Protein Phosphorylation
      • Ser / Thr Phosphatases
      • Stem Cells
      • Signaling Pathways
      • Wnt
      • Cytoplasmic
      • Epigenetics and Nuclear Signaling
      • Cell cycle
      • Kinases/Phosphatases
      • Other
      • Stem Cells
      • Signaling Pathways
      • TGF beta
      • Cytoplasmic
      • Signal Transduction
      • Metabolism
      • Vitamins / Minerals
      • Cancer
      • Cell cycle
      • Kinases/phosphatases
      • Phosphatases
      • Cardiovascular
      • Atherosclerosis
      • Diabetes associated
      • Cardiovascular
      • Heart
      • Contractility
      • Contractile Proteins
      • Troponin
      • Cancer
      • Cancer Metabolism
      • Metabolic signaling pathway
      • Metabolism of lipids and lipoproteins
      • Biochemicals
      • Chemical Type
      • Biochemicals
      • Biochemicals
      • Pharmacology
      • Enzymes
      • Phosphatase
      • PP1 & PP2A
      • Inhibitors
      • Metabolism
      • Pathways and Processes
      • Metabolic signaling pathways
      • Lipid and lipoprotein metabolism
      • Lipid metabolism
      • Metabolism
      • Pathways and Processes
      • Cofactors, Vitamins / minerals
      • Vitamins / minerals
      • Biochemicals
      • Pharmacology
      • Signaling
      • Signal transduction
      • PI3K/Akt signaling
      • PP1 & PP2A
      • Inhibitors
      • Biochemicals
      • Research Area
      • Cancer
      • Signal transduction
      • PI3K/Akt signaling
      • PP1 & PP2A
      • Inhibitors

    Images

    • Chemical Structure - Okadaic acid, PP1 and PP2A inhibitor (ab120375)
      Chemical Structure - Okadaic acid, PP1 and PP2A inhibitor (ab120375)
      2D chemical structure image of ab120375, Okadaic acid, PP1 and PP2A inhibitor

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (14)

    Publishing research using ab120375? Please let us know so that we can cite the reference in this datasheet.

    ab120375 has been referenced in 14 publications.

    • Jiménez-Cárcamo D  et al. Toxins of Okadaic Acid-Group Increase Malignant Properties in Cells of Colon Cancer. Toxins (Basel) 12:N/A (2020). PubMed: 32183214
    • Zhou Y  et al. Distinct and sequential re-replication barriers ensure precise genome duplication. PLoS Genet 16:e1008988 (2020). PubMed: 32841231
    • Zaccor NW  et al. The nonselective cation channel TRPV4 inhibits angiotensin II receptors. J Biol Chem 295:9986-9997 (2020). PubMed: 32493776
    • Berndsen K  et al. PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins. Elife 8:N/A (2019). PubMed: 31663853
    • Boban M  et al. Human neuroblastoma SH-SY5Y cells treated with okadaic acid express phosphorylated high molecular weight tau-immunoreactive protein species. J Neurosci Methods 319:60-68 (2019). PubMed: 30278184
    View all Publications for this product

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a review Submit a question

    Western Blot of okadaic acid-treated cells

    Excellent
    Abreviews
    Abreviews
    abreview image
    N2a cells were transfected with a plasmid encoding human Tau gene and then treated with 100nM Okadaic Acid (ab120375) overnight. Cell extracts (20ug) were then probed with phospho-tau specific antibody overnight. Okadaic acid-treated cells (right lane) show an increase in Tau phosphorylation compared to untreated cells (left lane). Expected MW = 55kDa.

    Abcam user community

    Verified customer

    Submitted Apr 26 2022

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