Overview

  • Product name

    Okadaic acid sodium salt, PP1 and PP2A inhibitor
  • Description

    Potent, selective PP1 and PP2A inhibitor
  • Biological description

    Potent, selective PP1 and PP2A inhibitor (IC50 values are 3 and 0.2-1 nM for PP1 and PP2A respectively). More stable during storage as a powder than free Okadaic Acid (Asc 375). Shows tumor-promoting effects in vivo. Centrally active.
  • Purity

    > 98%
  • CAS Number

    209266-80-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    9,10-Deepithio-9,10-didehydroacanthifolicin sodium salt
  • Molecular weight

    827.00
  • Molecular formula

    C44H67NaO13
  • PubChem identifier

    71308608
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO, methanol, ethanol, or acetone to 1 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C[C@@H]1CC[C@]2(CCCCO2)O[C@@H]1[C@@H](C)C[C@@H]([C@@H]3C(=C)[C@H]([C@H]4[C@H](O3)CC[C@]5(O4)CC[C@@H](O5)/C=C/[C@@H](C)[C@@H]6CC(=C[C@@]7(O6)[C@@H](CC[C@H](O7)C[C@](C)(C(=O)[O-])O)O)C)O)O.[Na+]
  • Source

    Halichondria okadai

  • Research areas

Images

  • Cells were grown to 70% confluence and serum starved for 18 h. For in vivo phosphatase activity, the growth medium was replaced with HENK's and the cells were preincubated in the presence or absence of 100 nM Okadaic Acid (ammonium salt) (ab141830), (or Okadaic Acid (sodium salt) (ab141831)) and 100 nM 1-Norokadaone (ab145527) followed by a 20 min incubation with or without 20 µM NEM. The cells were then stimulated with 5 ng/ml PDGF for 30 min. At the end of the incubation, cell proteins were resolved by SDS-PAGE and probed with anti-phospho-Akt antibodies.

References

This product has been referenced in:

  • Oberbeck DL  et al. Intra-amygdalar okadaic acid enhances conditioned taste aversion learning and CREB phosphorylation in rats. Brain Res 1348:84-94 (2010). Read more (PubMed: 20599840) »
  • Maeshima H  et al. Identification of tumor promotion marker genes for predicting tumor promoting potential of chemicals in BALB/c 3T3 cells. Toxicol In Vitro 23:148-57 (2009). Read more (PubMed: 19000923) »
  • Cohen P  et al. Okadaic acid: a new probe for the study of cellular regulation. Trends Biochem Sci 15:98-102 (1990). Read more (PubMed: 2158158) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab141831.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up