Overview

  • Product name

    Anti-Olig2 (phospho S10 + S13 + S14) antibody
    See all Olig2 primary antibodies
  • Description

    Rabbit polyclonal to Olig2 (phospho S10 + S13 + S14)
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Rat
    Predicted to work with: Mouse, Guinea pig, Human, Non human primates, Zebrafish
  • Immunogen

    Synthetic peptide within Human Olig2 (phospho S10 + S13 + S14) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: Q13516

  • Positive control

    • Rat neonatal brain lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab183487 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 32 kDa.

Target

  • Function

    Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development.
  • Tissue specificity

    Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.
  • Involvement in disease

    Note=A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA.
  • Sequence similarities

    Contains 1 basic helix-loop-helix (bHLH) domain.
  • Domain

    The bHLH is essential for interaction with NKX2-2.
  • Cellular localization

    Nucleus. Cytoplasm. The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2.
  • Information by UniProt
  • Database links

  • Alternative names

    • Basic domain helix loop helix protein class B 1 antibody
    • Basic helix loop helix protein class B 1 antibody
    • BHLHB antibody
    • bHLHB1 antibody
    • bHLHe19 antibody
    • Class B basic helix loop helix protein 1 antibody
    • Class B basic helix-loop-helix protein 1 antibody
    • class E basic helix loop helix protein 19 antibody
    • Class E basic helix-loop-helix protein 19 antibody
    • Human protein kinase C binding protein RACK17 antibody
    • Olig2 antibody
    • OLIG2_HUMAN antibody
    • Oligo2 antibody
    • Oligodendrocyte lineage transcription factor 2 antibody
    • Oligodendrocyte specific bHLH transcription factor 2 antibody
    • Oligodendrocyte transcription factor 2 antibody
    • OTTHUMP00000067569 antibody
    • OTTHUMP00000067570 antibody
    • PRKCBP2 antibody
    • Protein kinase C binding protein 2 antibody
    • Protein kinase C binding protein RACK17 antibody
    • Protein kinase C-binding protein 2 antibody
    • Protein kinase C-binding protein RACK17 antibody
    • RACK17 antibody
    see all

Images

  • All lanes : Anti-Olig2 (phospho S10 + S13 + S14) antibody (ab183487) at 1/1000 dilution

    Lane 1 : Rat neonatal brain lysate
    Lane 2 : Rat neonatal brain lysate with immunizing phosphopeptide

    Predicted band size: 32 kDa

References

This product has been referenced in:

  • Tsigelny IF  et al. Multiple spatially related pharmacophores define small molecule inhibitors of OLIG2 in glioblastoma. Oncotarget 8:22370-22384 (2017). WB ; Human . Read more (PubMed: 26517684) »
See 1 Publication for this product

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