Key features and details
- ATP synthase inhibitor
- CAS Number: 1404-19-9
- Purity: > 95%
- Soluble in ethanol to 10 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameOligomycin, ATP synthase inhibitor
DescriptionATP synthase inhibitor
Biological descriptionATP synthase inhibitor. Blocks the proton channel (Fo subunit). Macrolide antibiotic.
R)- 22-Ethyl-3',4',5',6'-tetrahydro-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione (for Oligomycin A)
Molecular formulaC45H74O11 (for Oligomycin A)
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in ethanol to 10 mM and in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
2D chemical structure image of ab141829, Oligomycin, ATP synthase inhibitor
Oligomycin inhibits ATP-dependent adipogenesis in 3T3-L1 cells.
Cells were induced to undergo adipocyte differentiation (A-D) for 5 days. Different concentrations of Oligomycin (ab141829) were then added (B, 1 µg/ml; C, 2 µg/ml and D, 10 µg/ml). After 10 days, the cells were stained with Oil Red O and visualized under light microscopy.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab141829 has been referenced in 9 publications.
- Alexander RK et al. Bmal1 integrates mitochondrial metabolism and macrophage activation. Elife 9:N/A (2020). PubMed: 32396064
- Chatterjee N et al. Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers. Cell Rep 28:2317-2330.e8 (2019). PubMed: 31461649
- Kurihara Y et al. Chlamydia trachomatis targets mitochondrial dynamics to promote intracellular survival and proliferation. Cell Microbiol 21:e12962 (2019). PubMed: 30311994
- Liu J et al. CCR7 Chemokine Receptor-Inducible lnc-Dpf3 Restrains Dendritic Cell Migration by Inhibiting HIF-1a-Mediated Glycolysis. Immunity 50:600-615.e15 (2019). PubMed: 30824325
- Nakamura-Ishizu A et al. Thrombopoietin Metabolically Primes Hematopoietic Stem Cells to Megakaryocyte-Lineage Differentiation. Cell Rep 25:1772-1785.e6 (2018). PubMed: 30428347
- McCarthy RC et al. Inflammation-induced iron transport and metabolism by brain microglia. J Biol Chem 293:7853-7863 (2018). PubMed: 29610275
- Sone M et al. Hybrid Cellular Metabolism Coordinated by Zic3 and Esrrb Synergistically Enhances Induction of Naive Pluripotency. Cell Metab 25:1103-1117.e6 (2017). PubMed: 28467928
- Okamoto A et al. The antioxidant N-acetyl cysteine suppresses lidocaine-induced intracellular reactive oxygen species production and cell death in neuronal SH-SY5Y cells. BMC Anesthesiol 16:104 (2016). PubMed: 27776485
- Waldeck-Weiermair M et al. Rearrangement of MICU1 multimers for activation of MCU is solely controlled by cytosolic Ca(2.). Sci Rep 5:15602 (2015). PubMed: 26489515