Overview

  • Product name

    Oligomycin B, macrolide antibiotic
  • Description

    Macrolide antibiotic. Mitochondrial ATPase inhibitor.
  • Biological description

    Macrolide antibiotic. Mitochondrial ATPase inhibitor.
  • Purity

    > 97%
  • CAS Number

    11050-94-5
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    805.05
  • Molecular formula

    C45H72O12
  • PubChem identifier

    71312640
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO and in ethanol
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCC1CCC2C(C(C(C3(O2)C(=O)CC(C(O3)CC(C)O)C)C)OC(=O)C=CC(C(C(C(=O)C(C(C(C(=O)C(C(C(CC=CC=C1)C)O)(C)O)C)O)C)C)O)C)C
  • Source

    Streptomyces diastatochromogenes

  • Research areas

Images

  • Effects of metabolic inhibitors on cellular ATP.

    Effect of metabolic inhibitors on cellular ATP was measured after 10 min in the presence of 10 mM glucose (A) or 0 mM glucose (B and C) (n = 4). Rote: 1 μM rotenone. Anti: 1 μM antimycin. Oligo: 6 μM oligomycin. CCCP: 1 μM CCCP. 2-DG: 5 mM 2-DG. Significant difference was assessed using ANOVA. Note that rotenone application in the presence of 10 mM glucose (panel A second from left) did not cause significant change, but all other treatments with metabolic inhibitors significantly changed luminescence reading against control values.

    (From Figure 5 of Yang et al).

References

This product has been referenced in:

See 1 Publication for this product

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