Overview

  • Product name

    Olomoucine II, CDK/cyclin inhibitor
  • Description

    CDK/cyclin inhibitor
  • Biological description

    CDK/cyclin inhibitor (IC50 values are 7.6 (CDK1/cyclin B), 0.1 (CDK2/cyclin E), 19.8 (CDK4/cyclin D1), 0.45 (CDK7/cyclin H) and 0.06 (CDK9/cyclin T) μM). Shows an IC50 of >100 μM for 10 other kinases. Antiproliferative and anticancer activity in vitro.
  • Purity

    > 98%
  • CAS Number

    500735-47-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Wang R & Guo YL Transient inhibition of cell proliferation does not compromise self-renewal of mouse embryonic stem cells. Exp Cell Res 318:2094-104 (2012). Read more (PubMed: 22705123) »
  • Krystof V  et al. Antiproliferative activity of olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor. Cell Mol Life Sci 62:1763-71 (2005). Read more (PubMed: 16003486) »
  • Krystof V  et al. Synthesis and biological activity of olomoucine II. Bioorg Med Chem Lett 12:3283-6 (2002). Read more (PubMed: 12392733) »

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